Posted inClinical Updates Rheumatology
Unveiling the Role of CCL20+ Macrophages as TNF Producers in Axial Spondyloarthritis Synovium: Implications for Targeted Therapy
This study identifies a CCL20+ macrophage subpopulation as a major source of TNF in axial spondyloarthritis synovium, driven by CD40L and an IL-1β/TNF-α autocrine loop, providing insights into disease pathogenesis and therapeutic targets.