Ropeginterferon alfa-2b Superior to Anagrelide as Second-line Therapy in Hydroxyurea‑Intolerant or ‑Refractory Essential Thrombocythaemia: SURPASS‑ET Phase 3 Results
Posted inHematology-Oncology news

Ropeginterferon alfa-2b Superior to Anagrelide as Second-line Therapy in Hydroxyurea‑Intolerant or ‑Refractory Essential Thrombocythaemia: SURPASS‑ET Phase 3 Results

SURPASS‑ET, a phase 3 randomized trial, showed ropeginterferon alfa‑2b achieved durable ELN responses in 43% of hydroxyurea‑intolerant/refractory ET patients with leukocytosis versus 6% with anagrelide, with a favorable safety profile and fewer serious adverse events.
Combining Food Biodiversity, Less Processing, and the EAT‑Lancet Diet Improves Nutrient Adequacy and Lowers Environmental Impact: Insights from 368,733 EPIC Participants
Posted inFamily Medicine & Nutrition news Public Health

Combining Food Biodiversity, Less Processing, and the EAT‑Lancet Diet Improves Nutrient Adequacy and Lowers Environmental Impact: Insights from 368,733 EPIC Participants

Multi-objective optimization in the EPIC cohort shows that modest gains in adherence to the EAT‑Lancet diet, increased plant species richness, and substitution of ultra‑processed foods with minimally processed foods can raise nutrient adequacy and reduce greenhouse gas emissions and land use.
Rigid Gas-Permeable Contact Lenses Improve Visual Rehabilitation After Primary Congenital Glaucoma Surgery: Results of the CLEVR‑PCG Randomized Trial
Posted innews Ophthalmology Pediatrics

Rigid Gas-Permeable Contact Lenses Improve Visual Rehabilitation After Primary Congenital Glaucoma Surgery: Results of the CLEVR‑PCG Randomized Trial

In children after primary congenital glaucoma surgery with poor spectacle response, rigid gas‑permeable contact lenses produced greater improvements in worse‑eye visual acuity, contrast sensitivity, and near stereoacuity over 12 months compared with continued spectacle wear.
Routine 5–7 Day Antibiotic Prophylaxis After Upper GI Bleeding in Cirrhosis: New Meta-analysis Questions the Mortality Benefit
Posted inGastroenterology Infectious Diseases news

Routine 5–7 Day Antibiotic Prophylaxis After Upper GI Bleeding in Cirrhosis: New Meta-analysis Questions the Mortality Benefit

A 2025 bayesian meta-analysis of 14 RCTs (n=1,322) found shorter or no antibiotic prophylaxis after upper GI bleeding in cirrhosis was highly likely to be noninferior for mortality, though it increased reported bacterial infections. Study limitations temper definitive practice change.
Guideline‑Level Moderate–Vigorous Physical Activity Appears Safe and Beneficial for Phenotype‑Negative Car cardiomyopathy Variant Carriers
Posted inCardiology news

Guideline‑Level Moderate–Vigorous Physical Activity Appears Safe and Beneficial for Phenotype‑Negative Car cardiomyopathy Variant Carriers

In a large UK Biobank cohort, accelerometer-measured moderate‑to‑vigorous physical activity (100–400 min/week) was associated with lower cardiovascular risk and no excess arrhythmic or cardiomyopathy onset among genotype‑positive phenotype‑negative (G+P-) cardiomyopathy variant carriers.
International Reference Values for Total Pancreatectomy Show Higher Perioperative Risk Than Pancreatoduodenectomy — Practical Benchmarks for Quality Control
Posted inGeneral Surgery news Oncology

International Reference Values for Total Pancreatectomy Show Higher Perioperative Risk Than Pancreatoduodenectomy — Practical Benchmarks for Quality Control

This multicenter study defines international perioperative reference values for total pancreatectomy (TP). Even low‑risk TP carries higher morbidity and mortality than pancreatoduodenectomy; outcomes worsen with vascular resection or conversion for high‑risk anastomosis.