Neurology – Page 7

Restoring Movement: How Polylaminin is Revolutionizing Spinal Cord Injury Treatment

By MedXY 02/07/2026

Brazilian scientists have developed Polylaminin, a protein derived from human placenta that stimulates nerve regeneration. In early trials, six paralyzed patients regained the ability to walk, prompting official Phase I clinical trials to begin this year.

Neurology news

Biologically Informed p-tau217 Cutoffs: Refining Alzheimer’s Diagnosis Across Diverse Patient Profiles

By MedXY 02/06/2026

Standard single cutoffs for plasma p-tau217 are significantly confounded by kidney function, BMI, and anemia. A new study demonstrates that subgroup-specific or double-cutoff strategies markedly improve diagnostic accuracy and cost-effectiveness in detecting amyloid-β pathology.

Neurology news

Higher Serum Klotho Levels May Protect Cognitive Function Against Age-Related Brain Atrophy

By MedXY 02/06/2026

Research indicates that circulating levels of the longevity protein klotho can moderate the relationship between cerebral atrophy and cognitive performance in older adults, suggesting a biological mechanism for cognitive resilience even in the presence of structural brain changes.

Neurology news

Targeted Ipsilesional Training: A New Frontier for Enhancing Function in Severe Chronic Stroke

By MedXY 02/06/2026

A randomized clinical trial reveals that targeted training of the ipsilesional arm significantly improves motor performance in chronic stroke patients with severe contralesional impairment, offering a sustained pathway to enhance functional capacity in a long-neglected patient population.

Neurology news Radiology

Apixaban Shows No Increased Risk of MRI-Detected Intracranial Hemorrhage Compared to Aspirin in Atrial Cardiopathy

By MedXY 02/05/2026

An exploratory analysis from the ARCADIA-MRI substudy reveals that apixaban carries a similar risk of incident intracranial hemorrhages, microbleeds, and superficial siderosis compared to aspirin in patients with atrial cardiopathy and cryptogenic stroke.

Neurology news Radiology

Time-Dependent Topography: How Specific ASPECTS Regions Predict Outcomes in Early vs. Extended Window Large Vessel Occlusion Stroke

By MedXY 02/04/2026

A post-hoc analysis of 1,040 LVO stroke patients reveals that the prognostic value of specific brain regions varies significantly between early (0-6h) and extended (6-24h) time windows, identifying the insula, caudate, and M6 as early-window markers, and M3 and M5 as late-window predictors.

Diabetes & Endocrinology Neurology news

Liraglutide and Alzheimer’s Disease: Can GLP-1 Agonists Bridge the Metabolic-Cognitive Gap?

By MedXY 02/04/2026

The Phase 2b ELAD trial investigated liraglutide's efficacy in mild-to-moderate Alzheimer's disease. While it failed its primary metabolic endpoint, significant improvements in executive function suggest a nuanced role for GLP-1 agonists in neuroprotection and cognitive preservation.

Neurology news Psychiatry

Tau Pathology Acts as a Switch: How Soluble Amyloid Drives Early Metabolic and Neuropsychiatric Symptoms in Alzheimer’s Disease

By MedXY 02/02/2026

Recent clinical evidence reveals that soluble amyloid-beta oligomers, rather than traditional plaques, drive glucose dysregulation and depression in early Alzheimer’s disease. Crucially, these associations are modulated by tau pathology, suggesting that tau staging is essential for identifying metabolic and psychiatric vulnerability in the AD spectrum.

Neurology news Ophthalmology

Tenecteplase Fails to Improve Visual Outcomes in Acute Central Retinal Artery Occlusion: Results from the TenCRAOS Trial

By MedXY 02/02/2026

The TenCRAOS trial demonstrated that intravenous tenecteplase administered within 4.5 hours of acute central retinal artery occlusion does not improve vision recovery compared to aspirin and carries significant safety risks, including fatal intracranial hemorrhage.

Cardiology Neurology news

Women Face Higher Dementia Risk from Combined Vascular and Genetic Factors: Insights from the ARIC Study

By MedXY 01/29/2026

A longitudinal study of 12,268 participants reveals that women are more susceptible to cognitive decline and dementia when burdened by high blood pressure and the APOE ε4 allele compared to men.

Infectious Diseases Neurology news

Adjunct Dexamethasone in Herpes Simplex Encephalitis: Safe but Fails to Improve Long-Term Verbal Memory in the DexEnceph Trial

By MedXY 01/29/2026

The Phase 3 DexEnceph trial found that adjunct dexamethasone is safe in adults with HSV encephalitis but does not significantly improve verbal memory scores at 26 weeks compared to aciclovir monotherapy, suggesting a need for earlier or more targeted immunomodulation.

Neurology news

Crenezumab Fails to Meet Primary Endpoints in Preclinical Autosomal-Dominant Alzheimer’s: Insights from the API ADAD Colombia Trial

By MedXY 01/28/2026

A Phase 2 trial of crenezumab in cognitively unimpaired PSEN1 mutation carriers found no significant clinical benefit over 5-8 years, suggesting that robust amyloid plaque removal may be essential for disease modification in early-stage Alzheimer's.

AI Neurology news

AI-Driven Prognosis: EEGSurvNet Accurately Predicts Seizure Timing From Routine EEG Data

By MedXY 01/28/2026

Researchers developed EEGSurvNet, a deep survival model that analyzes routine EEG to predict seizure risk over two years. Outperforming clinical models, it achieved an AUROC of 0.80 at two months and showed high efficacy in patients without visible epileptiform discharges.

Neurology news

NEOS2 Score: A Precision Tool for Predicting Treatment Response and Three-Year Functional Recovery in Anti-NMDAR Encephalitis

By MedXY 01/28/2026

The international NEOS2 study validates a refined clinical score using five baseline variables to accurately predict short-term immunotherapy response, one-year functional status, and three-year return to work or school in patients with anti-NMDAR encephalitis.

Infectious Diseases Neurology news

Preexisting Antiviral Immunity and Allogeneic T-Cell Transfer: Redefining the Therapeutic Landscape of Progressive Multifocal Leukoencephalopathy

By MedXY 01/26/2026

Recent studies highlight the critical role of virus-specific T-cells in treating progressive multifocal leukoencephalopathy. Pre-existing T-cells predict superior responses to checkpoint inhibitors, while allogeneic T-cell transfer offers a promising rescue therapy for patients with profound immunodeficiency, significantly reducing viral loads and improving clinical outcomes.

Neurology news Pediatrics

Early Developmental Intervention Linked to Sustained Executive Function Gains in Very Preterm Children

By MedXY 01/26/2026

A secondary analysis of a randomized clinical trial reveals that parent-led enhanced developmental intervention, beginning in the NICU and spanning two years, significantly improves executive function domains—including attention, inhibition, and problem-solving—in very preterm children by age seven.

Neurology news Public Health

Air Pollution as a Dual Threat: Linking Environmental Exposure to Motor Neuron Disease Risk and Accelerated Progression

By MedXY 01/26/2026

A comprehensive Swedish study reveals that long-term exposure to particulate matter and nitrogen dioxide significantly increases the risk of Motor Neuron Disease and accelerates functional decline, even in regions with relatively low pollution levels.

Cardiology Neurology news

Lipoprotein(a) and the 30-Year Horizon: Redefining Long-Term Cardiovascular and Stroke Risk in Women

By MedXY 01/25/2026

Longitudinal data from the Women’s Health Study reveal that elevated Lipoprotein(a) is a potent, independent predictor of myocardial infarction and ischemic stroke over three decades, suggesting a critical need for universal screening in primary prevention to address long-term residual risk.

Neurology news

Refining Prognosis in Anti-NMDAR Encephalitis: The NEOS2 Score Predicts Short- and Long-Term Recovery

By MedXY 01/23/2026

The NEOS2 score, an updated clinical tool, accurately predicts treatment response, one-year functional status, and three-year work/school resumption in anti-NMDAR encephalitis patients, offering clinicians a robust framework for early treatment intensification and patient stratification.

Neurology news

Miniaturized Closed-Loop Vagus Nerve Stimulation Drives Significant Functional Recovery in Chronic Stroke

By MedXY 01/22/2026

A randomized trial demonstrates that a 50-fold smaller, closed-loop vagus nerve stimulation (CLV) system is safe and significantly improves upper limb function in chronic stroke patients, with functional gains doubling during extended home-based therapy.