Neurology – Page 2

Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study

By MedXY 10/20/2025

Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.

Family Medicine & Nutrition Neurology Nursing & care Specialties

Evaluating Combined Mind-Body Exercise, Cognitive Training, and Nurse-Led Risk Factor Modification in Mild Cognitive Impairment: Insights from a Three-Arm Randomized Controlled Trial

By MedXY 10/20/2025

A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alone or general health advice in mild cognitive impairment. Future refinements and research are needed.

Internal Medicine Neurology news

Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults

By MedXY 10/20/2025

This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.

Neurology news Public Health

Evolving Landscape of Modifiable Dementia Risk Factors in Australia: Socioeconomic and Sex Disparities Over 15 Years

By MedXY 10/20/2025

This analysis reveals stable dementia risk fractions despite changing risk profiles over 15 years in Australia, highlighting greater modifiable risk among low-income groups and males, with depression emerging as a leading factor in mid-life, especially in women and disadvantaged populations.

Family Medicine & Nutrition Neurology Specialties

Dietary Patterns and Dementia Risk: Insights from a Large UK Biobank Cohort Study

By MedXY 10/20/2025

Higher adherence to Mediterranean, MIND, and Recommended Food Score diets is linked to reduced risk of all-cause dementia and Alzheimer disease, highlighting diet as a modifiable factor in dementia prevention.

Neurology news Public Health

Age-Dependent Impact of Vascular Risk Factors on Acute Stroke: Insights from the INTERSTROKE Study

By MedXY 10/20/2025

The INTERSTROKE study reveals how age modifies the relationship between vascular risk factors and acute stroke, highlighting age-specific prevention priorities to reduce stroke burden globally.

Neurology news

Advances in Alzheimer’s Diagnosis: A Comprehensive Review of CSF and Blood Biomarkers

By MedXY 10/20/2025

This article reviews a systematic meta-analysis of 15 cerebrospinal fluid and blood biomarkers for Alzheimer's disease, highlighting robust diagnostic performance of core markers T-tau, P-tau, and Aβ42 in clinical practice and research.

Nephrology Neurology news

Assessing the Role of Kidney Function in Alzheimer’s Disease Blood Biomarker Interpretation and Amyloid-β Positivity Prediction

By MedXY 10/20/2025

Kidney function influences certain Alzheimer's disease blood biomarker levels but, within normal to mild impairment ranges, does not improve prediction of amyloid-β positivity, supporting the clinical utility of blood biomarkers in AD diagnosis regardless of renal status.

Internal Medicine Neurology news

Unraveling Blood-Based Biomarkers in Neurodegenerative Diseases: Insights from the Young Finns Study on Intergenerational and Metabolic Influences

By MedXY 10/20/2025

This cohort study from the Young Finns Study elucidates factors influencing blood-based biomarkers for neurodegenerative diseases, highlighting age, APOE ε4 genotype, kidney function, metabolic parameters, and notable intergenerational associations.

Neurology Public Health Specialties

Life Course Air Pollution Exposure Linked to Cognitive Decline and Brain Structural Changes in Older Adults

By MedXY 10/20/2025

A population-based study reveals that midlife exposure to air pollutants such as nitrogen dioxide and particulate matter is associated with cognitive decline and brain structural alterations by age 69-71, highlighting long-term neurological risks of ambient air pollution.

Neurology news Public Health

Life Course Air Pollution Exposure and Cognitive Decline: Insights from the 1946 British Birth Cohort

By MedXY 10/20/2025

This population-based study reveals that midlife exposure to nitrogen dioxide and particulate matter correlates with poorer cognitive function and adverse brain structural changes in later life, underscoring the neurocognitive risks of air pollution.

Neurology news Public Health

Iyengar Yoga and Fall Risk in Older Adults: Unexpected Outcomes from a Rigorous RCT

By MedXY 10/20/2025

A large randomized controlled trial found that an Iyengar yoga-based exercise program increased fall rates among older adults compared to seated relaxation yoga, despite improvements in physical activity and balance confidence, highlighting the need for modified fall prevention yoga programs.

Neurology news Public Health

Optimizing Lifestyle Interventions to Prevent Cognitive Decline in Older Adults: Insights from a Comprehensive Network Meta-Analysis

By MedXY 10/20/2025

A large-scale network meta-analysis highlights that combined physical exercise and cognitive training most effectively improve cognition in older adults without impairment, emphasizing tailored lifestyle strategies for dementia prevention.

Neurology news Public Health

Mid-to-Late-Life Smoking Cessation Slows Long-Term Cognitive Decline: Insights from a 12-Country Longitudinal Study

By MedXY 10/20/2025

Smoking cessation in middle-aged and older adults is linked to a slower decline in memory and fluency over six years, suggesting quitting smoking benefits long-term cognitive health regardless of age at cessation.

Neurology news

Revolutionizing Spinocerebellar Ataxia Assessment: The Novel Digital Composite Balance Score SIBA

By MedXY 10/19/2025

The Score of Integrated Balance in Ataxia (SIBA) is a newly developed digital composite score that accurately measures standing and walking balance in spinocerebellar ataxia, enabling smaller, more efficient clinical trials with improved sensitivity to disease progression compared to existing scales.

Infectious Diseases Neurology news

Emerging Threat: Active West Nile Virus Transmission in Brazil Reveals Critical Public Health Challenge

By MedXY 10/18/2025

Recent evidence confirms active West Nile virus transmission across Brazil with significant neurological impact and fatalities, emphasizing the need for enhanced surveillance and public health action in South America.

Neurology Psychiatry Specialties

Predicting Seizure Recurrence After a First Unprovoked Seizure: Key Prognostic Factors and Clinical Implications

By MedXY 10/12/2025

This article examines prognostic factors predicting seizure recurrence after a first unprovoked seizure in children and adults, highlighting the roles of EEG abnormalities, brain imaging, nocturnal seizures, and family history, while addressing evidence limitations and future directions.

Neurology news Rehabilitation Medicine

Harnessing Combined Immersive and Nonimmersive Virtual Reality with Mirror Therapy in Stroke Rehabilitation: Evidence from a Systematic Review and Meta-Analysis

By MedXY 10/12/2025

Moderate-quality evidence from 14 RCTs supports combined immersive and nonimmersive VR with mirror therapy to enhance upper extremity function and hand dexterity in stroke survivors, though clinical significance needs cautious interpretation.

Neurology Nursing & care Specialties

Enhancing Care for Dementia: The Impact of Dementia Literacy Interventions on Caregivers

By MedXY 10/12/2025

A meta-analysis shows that dementia literacy interventions significantly reduce caregiver burden and improve knowledge, attitudes, and self-efficacy among caregivers of people with dementia.

Neurology news Psychiatry

Brexpiprazole in Alzheimer’s Disease-Related Agitation: Modest Gains Amidst Safety Uncertainties

By MedXY 10/12/2025

This review evaluates brexpiprazole's efficacy and safety for agitation in Alzheimer's disease, revealing modest symptom improvement but uncertain safety profiles, underscoring the need for individualized therapy and further research.