The Psychological Burden of Watchful Waiting: Anxiety and Depression Linked to Increased Rupture Risk and Mortality in Unruptured Intracranial Aneurysms

Highlights

Anxiety and depression diagnosed following the identification of an unruptured intracranial aneurysm (UIA) are associated with a 33% increased risk of aneurysm rupture and a 28% increase in all-cause mortality.

Patients with post-diagnostic psychological distress showed a trend toward lower rates of preventive surgical or endovascular treatment, potentially contributing to higher rupture rates.

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