Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY
Posted inDiabetes & Endocrinology Internal Medicine news

Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY

This article explores how polygenic background modifies GCK-MODY clinical phenotypes, influencing HbA1c levels and diagnostic thresholds. Findings highlight the distinct polygenic patterns in GCK-MODY compared to HNF1A-MODY, emphasizing the interaction between monogenic and polygenic factors in diabetes.
Optimizing the ‘When’ of Exercise: Afternoon and Evening Activity as a Precision Medicine Tool for Diabetes Risk Reduction
Posted inDiabetes & Endocrinology Internal Medicine news

Optimizing the ‘When’ of Exercise: Afternoon and Evening Activity as a Precision Medicine Tool for Diabetes Risk Reduction

New evidence from the UK Biobank and NHANES suggests that the timing of moderate-to-vigorous physical activity (MVPA) significantly impacts type 2 diabetes risk. Clustering activity in the afternoon and evening provides superior metabolic protection compared to morning sessions, independent of the total volume of exercise performed.
Breaking the Silos: How the PACE-It Model Improves Outcomes in Multimorbid Patients through Integrated Social and Clinical Care
Posted inDiabetes & Endocrinology Family Medicine & Nutrition news

Breaking the Silos: How the PACE-It Model Improves Outcomes in Multimorbid Patients through Integrated Social and Clinical Care

The PACE-It pilot program demonstrates that integrating health and social care via multidisciplinary teams and technology significantly improves glycemic control, lipid management, and patient activation for individuals with complex needs, offering a scalable model for bridging systemic silos in primary care.