Diminished Arginine Bioavailability in A-β+ Ketosis-Prone Diabetes: A Distinct Metabolic Signature Underlying Ketoacidosis Risk
Posted inDiabetes & Endocrinology news

Diminished Arginine Bioavailability in A-β+ Ketosis-Prone Diabetes: A Distinct Metabolic Signature Underlying Ketoacidosis Risk

This study reveals that reduced arginine availability during hyperglycaemia distinguishes A-β+ ketosis-prone diabetes from type 2 diabetes, implicating impaired arginine metabolism in ketoacidosis pathogenesis and highlighting citrulline supplementation as a potential therapeutic strategy.
Levothyroxine Treatment and Cardiometabolic Biomarkers in Older Adults with Subclinical Hypothyroidism: A Comprehensive Review
Posted inCardiology Clinical Updates Diabetes & Endocrinology news

Levothyroxine Treatment and Cardiometabolic Biomarkers in Older Adults with Subclinical Hypothyroidism: A Comprehensive Review

Levothyroxine treatment in older adults with subclinical hypothyroidism shows limited impact on cardiometabolic biomarkers overall but may benefit those with higher TSH levels, highlighting nuanced treatment implications and the need for tailored therapeutic strategies.
Once-weekly IcoSema versus Daily Insulin Glargine U100 in Type 2 Diabetes: Evidence from the COMBINE 4 Phase 3b Trial and Related Advances
Posted inClinical Updates Diabetes & Endocrinology news

Once-weekly IcoSema versus Daily Insulin Glargine U100 in Type 2 Diabetes: Evidence from the COMBINE 4 Phase 3b Trial and Related Advances

COMBINE 4 demonstrated that once-weekly IcoSema (icodec+semaglutide) offers superior glycemic control, weight reduction, and reduced hypoglycemia versus daily insulin glargine U100 in insulin-naive type 2 diabetes patients, supported by complementary phase 3 studies on insulin icodec.
Acute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose: A Synthesis of Clinical Evidence and Mechanistic Insights
Posted inCardiology Clinical Updates Diabetes & Endocrinology news

Acute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose: A Synthesis of Clinical Evidence and Mechanistic Insights

This review integrates recent randomized trial data with observational studies to clarify cannabis inhalation's acute impact on cardiac ectopy, physical activity, sleep, and glucose, highlighting complex arrhythmia associations and clinical implications.
Empowering Internal Medicine Residents to Combat Obesity: A Comprehensive Training Pathway in an Underserved Urban Clinic
Posted inDiabetes & Endocrinology Internal Medicine news

Empowering Internal Medicine Residents to Combat Obesity: A Comprehensive Training Pathway in an Underserved Urban Clinic

A novel longitudinal obesity medicine training pathway for internal medicine residents, implemented at an urban Federally Qualified Health Center, improves physician confidence and management skills in obesity care, preparing trainees for board certification and addressing unmet educational needs.