Dermatology – Page 4

Long-Term Survival Benefit of Spartalizumab with Dabrafenib and Trametinib in BRAF V600-Mutant Advanced Melanoma: Insights from the COMBI-I Trial

By MedXY 08/13/2026

The COMBI-I trial demonstrates that adding spartalizumab to dabrafenib and trametinib improves overall survival in patients with BRAF V600-mutant advanced melanoma after over 6 years of follow-up, despite not meeting the initial progression-free survival endpoint.

Dermatology news

A Practical Framework for Pyoderma Gangrenosum: Expert Consensus Defines Phenotypes and Modifiers

By MedXY 08/12/2026

An expert Delphi panel established a standardized, descriptive classification for pyoderma gangrenosum (PG) to improve diagnosis, research, and treatment planning by defining distinct phenotypes and key disease modifiers.

Allergy & Immunology Dermatology news

Early Prediction of Dupilumab Efficacy in Facial Atopic Dermatitis via Reflectance Confocal Microscopy and Deep Learning

By MedXY 08/12/2026

Reflectance confocal microscopy features at week 4 post-dupilumab treatment, combined with deep learning analysis, enable non-invasive prediction of therapeutic response in facial atopic dermatitis patients.

Clinical Updates Dermatology news

Approved Monoclonal Antibody Therapies for Hidradenitis Suppurativa: Efficacy, Safety, and Economic Assessments

By MedXY 08/11/2026

This review synthesizes current evidence on adalimumab, secukinumab, and bimekizumab for moderate-to-severe hidradenitis suppurativa, emphasizing clinical efficacy, safety, mechanistic insights, and cost-effectiveness across diverse health systems.

Dermatology news Oncology

Dynamic Risk Stratification of Melanocytic Lesions with Peripheral Globules: Insights from a Longitudinal Cohort Study

By MedXY 08/11/2026

Longitudinal monitoring reveals that persistence and growth dynamics of peripheral globules in melanocytic lesions predict melanoma risk more accurately than static features alone, informing tailored surveillance strategies.

Dermatology news Oncology

Enfortumab Vedotin-Induced Cutaneous Toxicity: A Marker of Improved Survival in Advanced Urothelial Carcinoma

By MedXY 08/07/2026

Enfortumab vedotin (EV) therapy in advanced urothelial carcinoma is frequently associated with cutaneous adverse events (cAEs). These EV-induced skin toxicities correlate independently with improved progression-free and overall survival, even after adjusting for confounders like immune checkpoint inhibitor use.

Dermatology Infectious Diseases news

Efficacy of Antifungal Therapies in Tinea Capitis: Insights from a Multicenter Study in China

By MedXY 08/07/2026

A multicenter prospective real-world study in China evaluated treatment outcomes of tinea capitis, highlighting itraconazole's superior efficacy over terbinafine for certain fungal strains like Microsporum canis, informing optimized antifungal strategies.

Allergy & Immunology Dermatology news

CD19 CAR T-cell Therapy Without Lymphodepletion Shows Promise in Pemphigus Vulgaris: Insights from the RESET-PV Trial

By MedXY 08/02/2026

Early results from the RESET-PV trial indicate that CD19 CAR T-cell therapy without lymphodepleting preconditioning is feasible and safe for pemphigus vulgaris, offering significant clinical improvement and durable B-cell depletion.

Clinical Updates Dermatology news Oncology

Cost-Effectiveness of Oral Nicotinamide for Keratinocyte Carcinoma Prevention: A Clinical and Economic Review

By MedXY 07/30/2026

Oral nicotinamide reduces keratinocyte carcinoma incidence in high-risk individuals, providing significant cost savings and quality-adjusted life-year gains, supporting its role as a cost-effective preventive strategy.

Dermatology news

Enhancing Diagnostic Accuracy in Head and Neck Pigmented Macules: The Critical Role of Reflectance Confocal Microscopy

By MedXY 07/30/2026

Reflectance confocal microscopy (RCM) combined with dermoscopy significantly improves detection and management of equivocal pigmented macules on the head and neck, reducing missed malignancies and overtreatment in a study of 2006 lesions.

Dermatology news

Digital Standardized Skin Care Regimen Enhances Outcomes in Patients with Acne-Rosacea Comorbidity: Insights from a Real-World Longitudinal Cohort

By MedXY 07/21/2026

A digital standardized skin care regimen improves clearance rates, reduces relapse, and enhances quality of life in acne-rosacea comorbidity, mediated partially by epidermal barrier restoration.

Dermatology news Oncology

Circulating Tumor DNA Outperforms Merkel Cell Polyomavirus Antibodies for Monitoring Recurrence in Merkel Cell Carcinoma

By MedXY 07/14/2026

A multicenter cohort study demonstrates that circulating tumor DNA (ctDNA) is more accurate than Merkel cell polyomavirus (MCPyV) antibody testing in detecting recurrence of Merkel cell carcinoma, improving patient surveillance and risk stratification.

Dermatology news Oncology

Exploring Institutional and Insurance-Linked Disparities in Melanoma Outcomes: Insights from a VA and Tertiary Care Cohort Study

By MedXY 07/14/2026

This cohort study reveals differential melanoma survival outcomes linked to institutional settings and insurance types, highlighting the need for standardized care in advanced melanoma stages.

Dermatology news Plastic Surgery

Dispelling Myths: Navigating Patient Misconceptions About Hyaluronic Acid Fillers for Optimal Aesthetic Outcomes

By MedXY 07/14/2026

This article addresses common patient misconceptions about hyaluronic acid fillers, elucidating safety, efficacy, and best practice strategies to ensure natural results and improved patient trust.

Allergy & Immunology Dermatology news

Optimizing Long-Term Management in Moderate-to-Severe Atopic Dermatitis: Real-World Evidence on 24-Week Abrocitinib Tapering Strategies

By MedXY 07/12/2026

This article reviews a retrospective study evaluating the feasibility and outcomes of a 24-week abrocitinib tapering regimen in moderate-to-severe atopic dermatitis, comparing dose reduction versus interval extension approaches and their impact on efficacy, safety, and cost.

Dermatology news Radiology

When to Image: Expert Consensus on Staging and Surveillance Imaging for Cutaneous Squamous Cell Carcinoma

By MedXY 07/12/2026

A multidisciplinary Delphi panel offers practical, consensus-based recommendations to standardize when and how to use staging and surveillance imaging for localized cutaneous squamous cell carcinoma (CSCC).

Allergy & Immunology Dermatology news

Feasibility and Comparative Outcomes of 24-Week Abrocitinib Tapering in Moderate-to-Severe Atopic Dermatitis

By MedXY 07/12/2026

This study evaluates the successful 24-week tapering of abrocitinib in moderate-to-severe atopic dermatitis patients, comparing dose reduction versus interval extension tapering regimens and demonstrating high feasibility with substantial dose and cost reductions.

Dermatology news Plastic Surgery

High-Frequency Ultrasound in Managing Palpable Indurations After Cosmetic Filler Injections: Diagnostic Precision and Guided Therapeutics

By MedXY 07/12/2026

This retrospective analysis demonstrates high-frequency ultrasound’s efficacy in diagnosing palpable indurations post-cosmetic filler injection, enabling tailored treatment strategies that improve clinical outcomes and minimize intervention risks.

Dermatology Infectious Diseases news

Large-Scale Meta-Analysis Finds Higher Influenza and Shingles Risk with JAK-STAT Inhibitors

By MedXY 05/27/2026

A large meta-analysis found JAK-STAT inhibitors slightly increased influenza, bronchitis, and herpes zoster risk, especially in atopic dermatitis, while serious and opportunistic infections were not significantly increased.

Critical Care Dermatology news

Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort

By MedXY 05/27/2026

In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.