Emerging APRIL-Targeted Therapies in IgA Nephropathy and IgA Vasculitis Nephritis: Clinical Advances with Zigakibart, Sibeprenlimab, and Telitacicept
Posted inAllergy & Immunology Clinical Updates Nephrology Specialties

Emerging APRIL-Targeted Therapies in IgA Nephropathy and IgA Vasculitis Nephritis: Clinical Advances with Zigakibart, Sibeprenlimab, and Telitacicept

Recent clinical trials of APRIL-targeted monoclonal antibodies—zigakibart, sibeprenlimab, and telitacicept—demonstrate safety and significant proteinuria reduction in IgA nephropathy and IgA vasculitis nephritis, offering promising disease-modifying therapeutic options.
PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings
Posted inAllergy & Immunology Clinical Updates news Rheumatology Specialties

PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings

PANLAR’s 2025 evidence-based recommendations for non-systemic polyarticular JIA emphasize early treat-to-target care using methotrexate, targeted escalation to biologics when needed, region-sensitive alternatives (leflunomide, triple nbDMARD therapy), and limited steroid bridging to improve outcomes in Latin America.
Diverging Pediatric Recommendations on COVID-19 Vaccination: The AAP Advocates Routine Immunization for Young Children Amid Federal Policy Shift
Posted inAllergy & Immunology Infectious Diseases Pediatrics Public Health Specialties

Diverging Pediatric Recommendations on COVID-19 Vaccination: The AAP Advocates Routine Immunization for Young Children Amid Federal Policy Shift

The American Academy of Pediatrics recommends COVID-19 vaccination for all young children aged 6-23 months, diverging from current CDC policies that advise shared decision-making for healthy children. This review analyzes epidemiologic data, guideline conflicts, and implications for pediatric COVID-19 vaccine policies.
Long-term Ambient Air Pollution Exposure and Asthma Exacerbation Risk in Women: Evidence from the Nurses’ Health Study II
Posted inAllergy & Immunology Family Medicine & Nutrition news Respiratory Specialties

Long-term Ambient Air Pollution Exposure and Asthma Exacerbation Risk in Women: Evidence from the Nurses’ Health Study II

Long-term exposure to ambient air pollutants, notably nitrogen dioxide, is linked to increased asthma exacerbations in women, independent of plant-based diet adherence, underscoring the need for stricter air quality standards and targeted resilience strategies.
Low-Dose Interleukin-2: Unlocking Immune Modulation Across Autoimmune, Neurodegenerative, Metabolic, Transplant, and Inflammatory Diseases
Posted inAllergy & Immunology Clinical Updates Family Medicine & Nutrition news Specialties

Low-Dose Interleukin-2: Unlocking Immune Modulation Across Autoimmune, Neurodegenerative, Metabolic, Transplant, and Inflammatory Diseases

Low-dose IL-2 immunotherapy demonstrates broad, disease-modifying effects by selectively expanding regulatory T cells (Tregs), offering a promising strategy across diverse diseases including autoimmunity, neurodegeneration, metabolic dysfunction, transplantation, and inflammatory disorders.