Allergy & Immunology

Basophil Activation Test: A Superior Predictor for Allergic Reactions to Baked and Fresh Cow’s Milk in Children

By MedXY 10/21/2025

The Basophil Activation Test offers the highest accuracy in predicting allergic reactions to baked and fresh cow's milk during oral food challenges, reducing the need for riskier diagnostic tests in children with milk allergy.

Allergy & Immunology Nephrology

Oral Iptacopan Shows Promise in Reducing Proteinuria in C3 Glomerulopathy: Results from a Global Phase 3 Trial

By MedXY 10/10/2025

The APPEAR-C3G phase 3 trial demonstrates that oral iptacopan significantly reduces proteinuria and is well tolerated in adults with C3 glomerulopathy, an ultra-rare glomerulonephritis linked to alternative complement pathway overactivation.

Allergy & Immunology news Respiratory

Persistent Use of Green Cleaning Products Linked to Increased Asthma Risk: Implications for Clinical Practice

By MedXY 10/09/2025

Longitudinal data from the French NutriNet-Santé cohort reveal that persistent and increased use of green cleaning products is associated with a modest but significant rise in asthma symptoms, underscoring the need for cautious use and patient counseling.

Allergy & Immunology Dermatology news

Patient-Centered Insights: Understanding Treatment Preferences in Chronic Urticaria Management

By MedXY 10/08/2025

This systematic review highlights patient and caregiver priorities in chronic urticaria treatment, emphasizing rapid symptom relief, long-term effectiveness, and safety.

Allergy & Immunology Internal Medicine news

Guardians Within: The Nobel-Winning Discovery of Regulatory T Cells and Their Role in Immune Balance

By MedXY 10/06/2025

The 2025 Nobel Prize in Physiology or Medicine honors groundbreaking work on regulatory T cells, revealing how the immune system avoids self-attack while combating threats, paving the way for novel therapies in autoimmune and transplant medicine.

Allergy & Immunology Medical News news Pediatrics Public Health Specialties

In-Home Firearm Homicides Among Children and Adolescents: Understanding a Hidden Crisis

By MedXY 09/29/2025

Nearly one-quarter of firearm-related homicides of US children and adolescents occur at home, particularly affecting younger children, with domestic violence and child abuse as major factors.

Allergy & Immunology Clinical Updates news OB/GYN & Women's Health Specialties

Menopause and Multiple Sclerosis: Evaluating the Impact on Disability Progression

By MedXY 09/29/2025

A comprehensive analysis reveals that menopause does not significantly alter the risk of disability progression in women with relapse-onset multiple sclerosis, underscoring the complexity of reproductive aging's role in disease trajectory.

Allergy & Immunology Dermatology Specialties

Icotrokinra: A Promising Oral IL-23 Inhibitor Outperforms JAK Inhibitor in Psoriasis Phase 3 Trials

By MedXY 09/25/2025

In two phase 3 trials, oral IL-23 receptor inhibitor icotrokinra demonstrated superior efficacy and safety compared to the JAK inhibitor deucravacitinib in moderate-to-severe plaque psoriasis, marking a potential advancement in oral psoriasis therapies.

Allergy & Immunology Clinical Updates OB/GYN & Women's Health

Pregnancy and Disease Outcomes in Women with Moderate to Severe Multiple Sclerosis Disability

By MedXY 09/24/2025

This study evaluates how pregnancy affects relapse rates and long-term disability in women with moderate to severe multiple sclerosis (MS), showing pregnancy reduces relapse during gestation without worsening long-term disability progression.

Allergy & Immunology Neurology Pediatrics Specialties

Modulating Immune Dysregulation in Autism Spectrum Disorder: Comparative Effects of an Anti-Inflammatory Diet and Probiotic Supplementation

By MedXY 09/16/2025

A 12-week trial in children with ASD demonstrates that a structured anti-inflammatory dietary protocol (NeuroGutPlus) exerts broader immunoregulatory effects than multi-strain probiotics, highlighting diet as a promising non-pharmacological intervention for immune dysregulation in ASD.

Allergy & Immunology Family Medicine & Nutrition news Specialties

Dynamic Effects of Short-Term Dietary Energy Loads on Fecal Serotonin, Gut Microbiome Tryptophanase, and Energy Absorption: Insights from a Randomized Crossover Trial

By MedXY 09/16/2025

Short-term alterations in dietary energy intake significantly impact fecal serotonin, gut microbiome tryptophanase activity, and energy absorption, highlighting a complex interaction that may influence metabolic health.

Allergy & Immunology Medical News news Oncology Specialties

Why Do Chimpanzees Rarely Get Cancer? Unveiling a Key Evolutionary Difference That Could Revolutionize Immunotherapy

By MedXY 09/14/2025

New research reveals that a protein called plasmin weakens human immune response against cancer compared to chimpanzees, offering promising strategies to enhance cancer immunotherapy.

Allergy & Immunology Clinical Updates Family Medicine & Nutrition news Specialties

Iron Supplementation and Accelerated Aging: The Inflammatory Link and Dietary Mitigation

By MedXY 09/07/2025

Excessive iron supplementation accelerates phenotypic aging via inflammation, but anti-inflammatory and antioxidant diets may mitigate this risk, highlighting the importance of balanced iron intake and dietary patterns in aging health.

$Innovative Allogeneic CD19-Targeting T Cells Show Promise in Refractory Systemic Lupus Erythematosus with Lupus Nephritis$

Allergy & Immunology Clinical Updates Rheumatology Specialties

Innovative Allogeneic CD19-Targeting T Cells Show Promise in Refractory Systemic Lupus Erythematosus with Lupus Nephritis

By MedXY 09/04/2025

A phase 1 trial demonstrates that the allogeneic CD19-targeting T cell therapy YTS109 is safe and induces clinical remission, immune resetting, and renal tissue restoration in patients with refractory systemic lupus erythematosus complicated by lupus nephritis.

Allergy & Immunology Clinical Updates Dermatology news Psychiatry Specialties

Elevated Risk of Depression and Anxiety in Hidradenitis Suppurativa: Implications Beyond Disease Severity

By MedXY 09/03/2025

Patients with hidradenitis suppurativa face a significantly increased risk of new-onset depression and anxiety, independent of disease severity, highlighting the need for universal psychiatric assessment in this population.

Allergy & Immunology Clinical Updates Dermatology news Orthopedics Specialties

Combination Targeted Therapy in Psoriatic Arthritis: Evaluating Infection Risks and Usage Patterns

By MedXY 09/03/2025

This article evaluates the prevalence and infection risks associated with combination targeted therapies in adults with psoriatic arthritis, revealing no significant increase in serious or opportunistic infections compared to standard therapy.

Allergy & Immunology Cardiology Clinical Updates Dermatology news Specialties

Interleukin-17 Inhibitors and Cardiovascular Risk: Evaluating Early Major Adverse Cardiovascular Events

By MedXY 09/03/2025

A national database study finds no significant increase in early major adverse cardiovascular events (MACEs) after starting IL-17 inhibitors in psoriasis and related diseases, although a modest risk cannot be excluded.

Allergy & Immunology Clinical Updates Dermatology Gastroenterology

Alopecia Areata Linked to Elevated Risk of Microscopic Colitis and Other Immune-Mediated GI Disorders: Clinical Insights

By MedXY 09/01/2025

A large retrospective cohort study identifies a significant association between alopecia areata and increased risks of microscopic colitis, celiac disease, Crohn’s disease, eosinophilic esophagitis, and ulcerative colitis, highlighting the need for gastrointestinal screening in affected patients.

Allergy & Immunology Clinical Updates news Oncology Specialties

Tumor Microenvironment-Responsive Mn-Based Nanoplatform Activates cGAS-STING Pathway Coupled with Metabolic Interference for Enhanced Antitumor Therapy

By MedXY 08/30/2025

A novel Mn-based nanoplatform, LT@MnO@MON-HA (LMMH), responsive to tumor microenvironment triggers metabolic disruption and robust cGAS-STING activation, potentiating chemodynamic therapy and immunotherapy for improved tumor suppression.

Allergy & Immunology Clinical Updates news Oncology Specialties

Manganese: A Potent Catalyst Enhancing Cancer Immunotherapy

By MedXY 08/30/2025

Manganese and its nanoparticles play a pivotal role in cancer immunotherapy by modulating immune pathways, reshaping the tumor microenvironment, and serving as effective adjuvants and drug carriers, offering promising avenues to overcome current therapeutic challenges.