Introduction and Context
Childhood and adolescent cancer survival has improved markedly over recent decades. As a result, growing numbers of survivors now face life-long risks of organ dysfunction, endocrine problems, secondary cancers, psychosocial challenges, and barriers to education, employment, and independent living. Landmark epidemiology (eg, Oeffinger et al., NEJM 2006) documented a high lifetime burden of chronic health conditions among adult survivors of childhood cancer, highlighting the need for continued, risk‑based follow‑up beyond paediatric care [1].
Yet transitions from paediatric/adolescent oncology to adult care are often fragmented. Survivors report gaps in information, unclear care responsibility, and poor access to providers knowledgeable about cancer‑related late effects. With these clinical gaps and variable practice across Europe, the EU‑CAYAS‑NET consortium convened an international, multidisciplinary guideline panel and patient representatives to produce a clinical practice guideline focused specifically on health‑care transitions for people diagnosed with cancer at ages 0–21 years. The guideline (Wams et al., Lancet Oncology 2025) synthesizes evidence spanning 1990–2025, applies GRADE methodology, and issues 44 strong recommendations to standardize and improve transitions for this vulnerable population [2].
