Highlights
- High genomic complexity (HGC) is strongly associated with U-CLL, TP53 aberrations, and shortened telomere length.
- In multivariate models, HGC often loses its independent prognostic value when adjusted for TP53 status and IGHV mutation status.
- Telomere attrition and DNA methylation subtypes remain critical independent predictors of survival in the era of chemoimmunotherapy.
Introduction: The Challenge of Risk Stratification in CLL
