Highlight
– The MIND randomized clinical trial compared minimally invasive surgery (MIS) using the Artemis Neuro Evacuation Device to guideline-based medical management alone for spontaneous supratentorial intracerebral hemorrhage (ICH).
– MIS achieved substantial hemorrhage volume reduction (median 80.7%) but did not significantly improve 180-day functional outcomes or reduce 30-day mortality versus medical management alone.
– Safety outcomes were comparable between groups, with low rates of procedure-related complications.
– Early trial termination limited power, though subgroup trends suggested possible benefit in patients with lobar hemorrhages.
