Mass administration of ivermectin in high malaria endemic settings results in modest reductions in malaria incidence, but effects may be context-dependent.
Ivermectin was well-tolerated, with no increase in serious adverse events compared to controls in both studies.
No significant reduction in malaria transmission was observed in a setting with high coverage of next-generation insecticide-treated nets and seasonal malaria chemoprevention.
Entomological data suggest transient effects on mosquito survival, with unclear impact on overall transmission dynamics.
