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Mantle Cell Lymphoma (MCL) exhibits heterogeneous clinical outcomes, creating challenges in patient risk stratification and treatment selection. MAIPI (MCL Artificial Intelligence Prognostic Index) is an innovative deep learning algorithm trained exclusively on routine Hematoxylin and Eosin (H&E) stained biopsy images, enabling prognostic prediction without specialized molecular or immunohistochemical analyses. Validated in large independent cohorts, MAIPI independently predicts survival, outperforming or complementing established clinical indices such as MIPI and Ki67 proliferation index.
