Highlights
– Interval colorectal cancers (CRCs) after positive fecal immunochemical test (FIT) with negative colonoscopy show higher incidence and mortality than those after negative FIT.
– Hospital-level adenoma detection rate (ADR) inversely correlates with interval CRC incidence and mortality but paradoxically associates with worse CRC-specific survival in diagnosed cases.
– These findings suggest inherent biological aggressiveness of tumors in FIT-positive patients and a potential ceiling effect of current colonoscopic techniques.
