Highlight
- Fibrosis in pancreatic ductal adenocarcinoma (PDAC) stiffens the tumor microenvironment, activating Schwann cells (SCs) through mechanical forces.
- Activated SCs demonstrate increased c-Jun phosphorylation via a non-canonical nuclear mechanosensing mechanism involving phospholipase A2.
- Pancreatic fibrosis alone, without malignant cells, is sufficient to trigger SC activation, implicating roles in non-malignant pancreatic diseases.
- SCs are more mechanically sensitive than PDAC cells, revealing a critical interaction that may be targeted in future microenvironment-focused therapies.
Study Background
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