Mild autonomous cortisol secretion (MACS) in adrenal tumors correlates with a higher prevalence and incidence of psychiatric disorders.
Psychiatric morbidity includes anxiety, mood, and substance use disorders, with the strongest association among men under 65 years.
Findings suggest clinical evaluation for psychiatric symptoms should be integrated into management of patients with adrenal tumors exhibiting cortisol autonomy.
The study emphasizes the neuropsychiatric impacts of subtle cortisol excess beyond known cardiometabolic risks.
