Evaluating Beta Cell Function in Preclinical Type 1 Diabetes Using CGM-Derived Disposition Index

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This study introduces a continuous glucose monitoring (CGM)-derived disposition index (DICGM) that accurately estimates beta cell function in individuals with islet autoimmunity who do not require insulin. The DICGM correlates strongly with the gold-standard oral glucose tolerance test (OGTT) disposition index (DIMM) and predicts clinically relevant glycemic deterioration one year later, providing a less invasive monitoring alternative.

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