Highlight
- Whole-exome sequencing reveals increasing mutation burden from IgM-MGUS to symptomatic Waldenström macroglobulinemia.
- Specific gene mutations (CD79B, ARID1A, CREBBP) and higher MYD88L265 variant allele frequency correlate with progression in asymptomatic WM.
- MYD88 wild-type IgM-MGUS patients have distinct genomic profiles compared to their MYD88-mutant counterparts.
- Aneuploidy burden associates significantly with the risk of progression to symptomatic disease.
Study Background
