Highlight
– In an individual-level meta-analysis from the Chronic Kidney Disease Prognosis Consortium (CKD-PC), 11% of outpatients and 35% of hospitalized patients had cystatin C–based eGFR (eGFRcys) at least 30% lower than creatinine-based eGFR (eGFRcr).
– Among outpatients, this large negative eGFR difference was associated with substantially higher rates of all-cause mortality (HR 1.69), cardiovascular mortality (HR 1.61), atherosclerotic events (HR 1.35), heart failure (HR 1.54) and kidney failure requiring replacement therapy (HR 1.29).
