The BIOLAP trial is the first large, randomized, self-controlled study comparing biological and synthetic meshes in bilateral laparoendoscopic inguinal hernia repair.
At 6 months postoperatively, there was no significant difference in patient-reported pain between biological and synthetic meshes.
Biological meshes exhibited significantly higher 2-year hernia recurrence rates (11.2% vs 2.5%) and increased seroma formation (33.4% vs 21.6%) compared with synthetic meshes.
These findings do not support switching from synthetic to biological meshes in routine laparoendoscopic inguinal hernia repair.
