Bariatric Surgery as an Effective Salvage Approach Following Semaglutide or Tirzepatide Therapy Failure

Bariatric surgery yields significant 2-year total body weight loss (TBWL) in adults unresponsive or intolerant to semaglutide or tirzepatide.
Roux-en-Y gastric bypass (RYGB) provides greater weight loss compared to sleeve gastrectomy (SG) in patients with inadequate response to these medications.
Weight loss efficacy is influenced by type 2 diabetes (T2DM) status, with generally lower TBWL observed in T2DM patients post-surgery.
These findings clarify therapeutic sequencing after emerging GLP-1 and dual agonist treatment failures in obesity management.

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