Assessing Cardiovascular Risk Prediction Models in Postmenopausal Women With Chronic Kidney Disease: Insights from the Women’s Health Initiative

Highlight

– Common cardiovascular risk prediction models demonstrate poor discrimination and calibration in postmenopausal women with CKD.
– Risk is consistently underpredicted by multiple models, including the PREVENT model, for women with and without CKD.
– The QRISK3 and PREVENT models performed better in women without CKD but still lacked precision in the CKD subgroup.
– There is a critical need for validated, CKD-specific cardiovascular risk tools for improved clinical decision-making in women.

Study Background