Advancing Diagnosis in Myeloproliferative Neoplasms: Non-invasive Multiparametric Profiling of ET, Premyelofibrosis, and Overt Myelofibrosis

Highlight

This prospective study analyzed 128 patients with essential thrombocythemia (ET), premyelofibrosis (preMF), and overt primary myelofibrosis (PMF) using non-invasive biomarker panels. Significant differences in inflammatory, immune activation, and matrix remodeling markers help distinguish PMF from ET and preMF. The results support a pathophysiological continuum between these MPN subtypes.

Study Background