Pregnancy confers a significantly increased risk of developing long COVID-19 multisystemic sequelae following SARS-CoV-2 infection, especially during Omicron-predominant periods.
Despite increased relative risk, the absolute incidence of postacute sequelae in vaccinated pregnant women infected with predominantly mild Omicron variant remains modest (<1%).
Infection during the third trimester correlates with heightened susceptibility to postacute sequelae compared to infections earlier in pregnancy.
COVID-19 booster vaccination prior to SARS-CoV-2 infection did not significantly reduce the risk of postacute sequelae beyond primary vaccination in pregnancy.
