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In long-term follow-up after 18-month lifestyle trials, participants regained weight but still preserved part of their earlier reductions in waist circumference and abdominal fat depots, especially visceral adipose tissue.
Among several fat depots measured by MRI, intervention-induced visceral fat loss showed the most clinically durable association with later cardiometabolic health and was the only depot independently linked to lower incident type 2 diabetes risk.
