Highlights
1. Postmenopausal women with differentiated thyroid cancer (DTC) on long-term TSH suppression therapy showed significantly worse cardiovascular health (LE8 score), higher carotid intima-media thickness, and lower quality-of-life scores than euthyroid controls or hypothyroid patients on replacement therapy.
2. Higher cumulative levothyroxine doses were independently associated with poorer cardiovascular and quality-of-life metrics, while higher TSH levels showed protective associations.
