tau PET – Medxy AI

Women’s Elevated P-Tau217 Levels and Faster Cognitive Decline: Implications for Preclinical Alzheimer’s Disease

By MedXY 04/28/2026

Women with high amyloid-β show higher p-tau217 levels and faster tau accumulation than men, leading to greater cognitive decline. This sex-specific tau response may redefine preclinical Alzheimer's diagnostics and therapeutics.

Neurology news

Sex-Specific P-Tau217 Dynamics: Why Women Exhibit Accelerated Tau Accumulation and Cognitive Decline

By MedXY 02/20/2026

A multi-cohort study demonstrates that women with amyloid-β pathology show higher plasma p-tau217 levels and faster tau PET accumulation than men, providing a biological basis for their increased risk of rapid cognitive decline in preclinical Alzheimer’s disease.

Neurology news

Tracking Steps to Slow Alzheimer’s: Physical Activity Linked to Reduced Tau Accumulation and Slower Decline in Preclinical AD

By MedXY 11/13/2025

In cognitively unimpaired older adults with elevated amyloid, higher daily step counts were associated with slower inferior-temporal tau accumulation and attenuated cognitive and functional decline, with benefit plateauing around 5,000–7,500 steps/day.