Posted inHematology-Oncology news
Pre-Diagnostic Low-Normal Immunoglobulin Levels Identify Early Clonal B-cell Dysregulation and CLL Susceptibility: Insights from a Large Retrospective Cohort
Low-normal immunoglobulin levels, particularly IgA, measured up to a decade before diagnosis, are predictive of chronic lymphocytic leukemia risk through dual mechanisms involving monoclonal B-cell lymphocytosis and constitutional susceptibility.