Levothyroxine in the Ageing Patient: Re-evaluating Cardiovascular Outcomes in Subclinical Hypothyroidism through the ACEL-UK-ETT Trial
Posted inCardiology Clinical Updates Diabetes & Endocrinology news

Levothyroxine in the Ageing Patient: Re-evaluating Cardiovascular Outcomes in Subclinical Hypothyroidism through the ACEL-UK-ETT Trial

This review analyzes the ACEL-UK-ETT emulated target trial, demonstrating that long-term levothyroxine therapy in older adults with subclinical hypothyroidism significantly reduces cardiovascular events and all-cause mortality without compromising bone health, provided age-specific TSH thresholds are utilized.
Rethinking First-Line Anticoagulation in Older Adults: Real-World Evidence Challenges Conventional AFib Management
Posted inCardiology Neurology news

Rethinking First-Line Anticoagulation in Older Adults: Real-World Evidence Challenges Conventional AFib Management

A large-scale study of 144,969 Medicare beneficiaries reveals that initial anticoagulant prescriptions for atrial fibrillation may not reduce ischemic stroke risk in patients over 66, while significantly increasing major bleeding hazards, suggesting a need for more nuanced, individualized clinical decision-making.