SSRIs vs. Second-Generation Antipsychotics for Managing Agitation in Dementia: Real-World Evidence from Nursing Homes
Highlight Agitation is prevalent among dementia patients in nursing homes, often managed with pharmacologic agents.…
Posted inNeurology news Psychiatry
Unraveling Dementia in Severe Schizophrenia: Distinct Cognitive Profiles and Genetic Insights
This study reveals that dementia in severe, treatment-resistant schizophrenia exhibits a unique cognitive profile distinct from common neurodegenerative dementias and lacks typical genetic markers such as APOE4, highlighting a novel dementia phenotype in this population.
Posted inInternal Medicine Neurology news
Navigating Complex Decisions: Physician Strategies in Setting Stroke Care Goals for Patients with Preexisting Disability or Dementia
This article explores how physicians determine stroke care goals for patients with disability or dementia, highlighting key challenges, decision factors, and the need for individualized, bias-aware approaches.
Posted inNeurology news Public Health
Digital Sleep-Wake Cycle Metrics and Dementia Prediction in Older Adults
Wearable accelerometer sleep-wake patterns were linked to later dementia risk in two UK cohorts and modestly improved prediction beyond age and standard risk factors.
Posted inNeurology news Public Health
Cerebral “Dirty-Appearing” White Matter and Its Link to Cognitive Decline and Dementia Risk
In older adults with limited small vessel disease, “dirty-appearing” white matter on MRI was not linked to baseline cognition, cognitive decline, or dementia risk, unlike conventional white matter hyperintensities.
Posted inCardiology Neurology news
Even ‘Elevated’ Blood Pressure Raises Dementia Risk: Insights from 2.8 Million Adults Over 8 Years
A landmark South Korean study of 2.8 million adults reveals that both elevated blood pressure and hypertension significantly increase dementia risk, particularly vascular dementia, with stronger effects observed in midlife adults and women. The findings validate the 2024 ESC blood pressure classification system.
Posted inNeurology news Public Health
Beyond Communication: Language Barriers Linked to Higher Hospital Utilization at End-of-Life in Dementia
A retrospective cohort study reveals that dementia patients with preferred language other than English are more likely to have documented goals-of-care discussions yet experience significantly higher hospital-based healthcare utilization near end-of-life, including increased ED visits, hospitalizations, ICU admissions, and in-hospital deaths.
Iatrogenic Alzheimer Pathology Can Mirror Severe Sporadic Disease After Cadaveric Growth Hormone Exposure
Four men exposed in childhood to cadaveric pituitary-derived human growth hormone developed dementia decades later; one autopsied case showed severe Alzheimer-type pathology, including tauopathy, supporting a transmissible iatrogenic Alzheimer disease phenotype.
The Changing Landscape of Mortality in Diabetes: A Shift from Cardiovascular Dominance to Cancer and Dementia
This review analyzes multinational data showing a significant decline in cardiovascular mortality among diabetes patients, alongside a concerning rise in dementia-related deaths and the emergence of cancer as a leading cause of mortality in high-income settings.
The Landscape of Late-Life Dementia: Why Mixed Neuropathologies Are the Rule, Not the Exception
A large-scale longitudinal study reveals that over 80% of community-dwelling older adults harbor mixed neuropathologies, identifying five distinct profiles that dictate specific cognitive decline trajectories, with ADNC and LATE-NC clusters showing the most aggressive progression.
Posted inNeurology news Psychiatry
Adversity Across the Lifespan: The Compounding Impact of Childhood and Adult Stress on Dementia and Stroke Risk
This population-based cohort study highlights how cumulative psychosocial stress across the life course significantly escalates the risk of neurovascular and neurodegenerative diseases, identifying depression as a critical target for intervention.
Posted inNeurology news Public Health
Moderate Caffeinated Coffee and Tea Intake Linked to 18% Lower Dementia Risk in Decades-Long Study
A prospective study of over 130,000 adults reveals that consuming 2-3 cups of caffeinated coffee or 1-2 cups of tea daily significantly reduces dementia risk and cognitive decline, whereas decaffeinated coffee shows no protective effect.
Posted inCardiology Neurology news
Women Face Higher Dementia Risk from Combined Vascular and Genetic Factors: Insights from the ARIC Study
A longitudinal study of 12,268 participants reveals that women are more susceptible to cognitive decline and dementia when burdened by high blood pressure and the APOE ε4 allele compared to men.
Posted inNeurology news Psychiatry
Reevaluating the Efficacy of Music Interventions in Dementia-Related Depression: Critical Insights from the MIDDEL Multinational Trial
Highlights The MIDDEL trial found that neither group music therapy nor recreational choir singing significantly…
Posted inEmergency Medicine Internal Medicine Neurology news
One in Three Older Emergency Admissions Face Cognitive Morbidity: Insights from the ORCHARD-EPR Study
A large-scale cross-sectional study of 51,202 admissions reveals that 35.6% of patients aged 70 and older experience cognitive morbidity, predominantly delirium. The findings underscore the urgent necessity for hospital-wide screening and multidisciplinary geriatric support across nearly all medical and surgical specialties.
Posted inCardiology Neurology news
Lipoprotein(a) and Dementia: Large Cohorts Show No Clear Link — But Small Apo(a) Isoforms May Raise Alzheimer’s Risk
A pooled analysis of three large cohorts found no consistent association between circulating lipoprotein(a) and Alzheimer’s disease or vascular dementia, but genetic evidence for very small apo(a) isoforms suggests a modest increase in Alzheimer’s risk.
Posted inNeurology news Specialties
APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients
The APOE ε4 allele significantly reduces survival in Parkinson's disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.
APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo
This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African populations.
Posted inNeurology news Public Health
Evolving Landscape of Modifiable Dementia Risk Factors in Australia: Socioeconomic and Sex Disparities Over 15 Years
This analysis reveals stable dementia risk fractions despite changing risk profiles over 15 years in Australia, highlighting greater modifiable risk among low-income groups and males, with depression emerging as a leading factor in mid-life, especially in women and disadvantaged populations.
Dietary Patterns and Dementia Risk: Insights from a Large UK Biobank Cohort Study
Higher adherence to Mediterranean, MIND, and Recommended Food Score diets is linked to reduced risk of all-cause dementia and Alzheimer disease, highlighting diet as a modifiable factor in dementia prevention.