Posted inHematology-Oncology news
Beyond Genetics: Targeting BMP and TAZ/TEAD Mechanotransduction to Reverse Chemoresistance in Acute Myeloid Leukemia
Recent research identifies BMPR1B and TAZ/TEAD as critical mechanotransduction drivers in relapsed AML. By targeting these pathways, clinicians may overcome the protective effects of bone marrow stiffening and intramedullary pressure, offering a new strategy for treatment-resistant patients.