Barrett’s esophagus

Pathology-Driven Epithelial Sulfide Loss Reprograms the Redox Proteome and Triggers Barrett’s Esophagus

By MedXY 06/05/2026

A study shows that reflux-related sulfide loss rewires esophageal redox proteins, increases PGE2 signaling, and helps drive Barrett’s esophagus, revealing a new potential therapeutic target.

Gastroenterology news Oncology

Universal ESD for Large Barrett’s Cancers: Shifting the Paradigm Toward Curative R0 Resection

By MedXY 03/10/2026

A multicenter study demonstrates that prioritizing endoscopic submucosal dissection (ESD) for Barrett’s cancers >15mm significantly improves R0 resection rates and survival, particularly in T1b disease, compared to traditional endoscopic mucosal resection (EMR).

Clinical Updates Gastroenterology news

Decoding the Role of Reflux Secondary Bile Acids in Barrett’s Esophagus: Microbiome and Transcriptome Insights

By MedXY 09/25/2025

This study reveals that elevated reflux secondary bile acids in Barrett's esophagus influence the esophageal microbiome and gene expression, highlighting potential mechanisms underpinning progression to esophageal adenocarcinoma.