Beyond a Positive Result: α-Synuclein Seeding Kinetics Predict Cognitive Decline in Parkinson’s Disease
A large-scale longitudinal study reveals that α-synuclein seed amplification assay (SAA) kinetic measures, particularly time to threshold, can differentiate Parkinson's from PSP and predict future cognitive decline independently of Alzheimer’s pathology, offering a new dimension to neurodegenerative diagnostics.