Respiratory – Page 5

Enhancing Treatment Evaluation in Fibrotic Interstitial Lung Disease: A Joint Model of Lung Function Decline and Mortality

By MedXY 07/09/2026

This article reviews a novel Bayesian joint mixed-effects model for analyzing lung function decline and mortality in fibrotic ILD, improving accuracy in estimating disease progression and treatment effects in clinical settings.

Gastroenterology news Respiratory

Unraveling the KLF9-NR4A1-p38 MAPK Axis: A Novel Mechanism Linking Intermittent Hypoxia to MASLD in Obstructive Sleep Apnea

By MedXY 07/08/2026

This study elucidates how KLF9 mediates intermittent hypoxia-induced MASLD by suppressing NR4A1 and p38 MAPK signaling, paving the way for targeted therapies in OSA-associated metabolic liver disease.

Cardiology news Respiratory

Impact of Short-Term High-Altitude Exposure on Right Ventricular Load and Oxygen Delivery in Pulmonary Vascular Disease Patients

By MedXY 07/05/2026

A two-day stay at 2500 m altitude increases right ventricular afterload and impairs ventricular-arterial coupling but maintains oxygen delivery in stable pulmonary vascular disease patients.

Cardiology news Respiratory

Enhancing Risk Prediction After TAVI: The COPD-Augmented R₂CHA₂DS₂-VA Score and Its Prognostic Value

By MedXY 07/03/2026

A novel risk score incorporating COPD and graded renal dysfunction improves prediction of one-year mortality post-TAVI, showing excellent internal validity but requiring external validation before clinical use.

news Oncology Respiratory

Symptom Prevalence in Lung Cancer Screening: Insights from the SUMMIT Study

By MedXY 07/02/2026

The SUMMIT study reveals that respiratory symptoms are common among lung cancer screening participants and associated with increased lung cancer diagnosis risk within one year, challenging conventional asymptomatic screening definitions.

news Respiratory

AD109 (Aroxybutynin and Atomoxetine): A Promising Oral Therapy for Obstructive Sleep Apnea in PAP-Intolerant Patients

By MedXY 07/02/2026

The SynAIRgy phase 3 trial demonstrated that the fixed-dose combination of aroxybutynin and atomoxetine (AD109) significantly reduces airway obstruction and improves oxygenation in obstructive sleep apnea patients unable to tolerate positive airway pressure therapy.

Clinical Updates news Respiratory

Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP-Intolerant OSA Patients: A Clinical Evidence Review

By MedXY 07/02/2026

This review synthesizes current evidence on the modified sleep apnea severity index (mSASI) as a composite metric integrating clinical and sleep study factors to predict cardiovascular risk in CPAP-intolerant OSA patients undergoing surgery.

Family Medicine & Nutrition news Respiratory

Empowering Climate-Conscious Inhaler Prescribing: A Patient-Physician Conversation Aid

By MedXY 06/30/2026

A novel conversation aid was developed and refined iteratively with patients and physicians to support shared decision-making for low carbon footprint inhaler prescribing in asthma and COPD, balancing environmental impact with safety and patient preferences.

news Oncology Respiratory

Hypoxic Microenvironment Triggers Early Aggressive Progression in EGFR-Mutant Lung Adenocarcinoma

By MedXY 06/29/2026

This study reveals that hypoxia in centrally located EGFR-mutant lung adenocarcinomas drives an alveolar lineage imbalance via the ZAKα-MAPK-c-Fos pathway, promoting early tumorigenesis. Therapeutic oxygenation can restore lineage balance and limit aggressive progression.

Clinical Updates news Respiratory

Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough: A Comprehensive Clinical Review

By MedXY 06/29/2026

Pregabalin, a neuromodulator, significantly improves symptoms in the majority of patients with chronic neurogenic cough, offering a well-tolerated treatment option irrespective of gender or gastrointestinal comorbidities.

Cardiology news Respiratory

Decoding Pulmonary Arterial Hypertension in Congenital Heart Disease: Latent Class Analysis Uncovers Distinct Risk Phenotypes and Treatment Insights

By MedXY 06/25/2026

Latent class analysis of 889 adult PAH-CHD patients identified unique phenogroups with distinct survival outcomes and treatment responses, offering refined risk stratification and guiding personalized therapy.

Critical Care news Respiratory

Early Lung Mechanical Responses to PEEP Reduction in ARDS: Insights from Four-Dimensional CT Imaging

By MedXY 06/25/2026

A 4D-CT study reveals early lung mechanics changes after PEEP reduction in ARDS, showing significant alveolar derecruitment and decreased over-inflation with minimal tidal recruitment increase, informing lung-protective ventilation strategies.

Cardiology news Respiratory

Unveiling the Phenotype of Unclassified Pulmonary Hypertension: A Hidden Spectrum of Early Heart Failure with Preserved Ejection Fraction

By MedXY 06/20/2026

Unclassified pulmonary hypertension often reflects early-stage HFpEF linked to left heart and metabolic dysfunction, identifiable via dynamic right heart catheterization and metabolomics.

news Respiratory

Why One Sleep Study May Not Tell the Whole Story: Night-to-Night Variability, AHI Definitions, and OSA Reclassification

By MedXY 06/19/2026

A recent Chest study shows that PSG metrics vary unevenly across nights, and AHI scored with 4% desaturation is less stable than AHI 3%/arousal. Hypoxic burden was more reproducible and may better reflect true OSA severity.

news Pediatrics Respiratory

Early Neutrophil and Persistent Eosinophil Gene Signatures in Childhood Asthma

By MedXY 06/19/2026

A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.

Clinical Updates news Radiology Respiratory

Laterality of Swimming-Induced Pulmonary Edema During Combat Sidestroke: Comparative Insights from Lung Ultrasound and Chest Radiography

By MedXY 06/14/2026

This review synthesizes evidence on SIPE lateralization corresponding to dependent body position during combat sidestroke, highlighting moderate concordance between lung ultrasound and chest x-ray findings and implications for field diagnostics.

news Respiratory

Mepolizumab and Blood Eosinophil Variability in COPD: A New Dimension in Targeted Therapy

By MedXY 06/13/2026

This article reviews mepolizumab efficacy in COPD patients with variable blood eosinophil counts, showing benefits even with intermittent eosinophilia, expanding treatable phenotypes beyond persistent elevation.

news Oncology Respiratory

Blood Cancer Proteins Plus Histoplasma Antibodies Improve Malignancy Assessment in Indeterminate Pulmonary Nodules

By MedXY 06/11/2026

In two US cohorts, combining serum cancer biomarkers and Histoplasma antibodies with the Mayo model improved discrimination of benign versus malignant pulmonary nodules, especially in intermediate-risk cases.

Critical Care news Respiratory

Remote Respiratory Therapy Safely Replaced Most Bedside Ventilator Care in a Donor Center ICU

By MedXY 06/09/2026

A prospective study found that fully remote respiratory therapy in a donor care ICU was feasible, safe, and labor-saving, with minimal need for bedside support and favorable organ recovery outcomes.

news Public Health Respiratory

Bronchoscopy in Germany Generates More Than 550 Tons of Waste Annually, With Reusable PPE Offering the Largest Immediate Reduction

By MedXY 06/08/2026

A multicenter German study shows pulmonary endoscopy produces substantial waste, much of it in procedure rooms, and suggests reusable gowns, procedural bundling, and recycling as practical ways to lower environmental impact.