A randomized controlled trial demonstrates that vitamin C supplementation enhances mental vitality in young adults with low vitamin C status, mediated by specific changes in gut microbiota and reduced inflammation.
This review explores vitamin C's potential to protect the heart from doxorubicin-induced damage by reducing oxidative stress and preserving cardiac function, highlighting the need for further clinical studies.
Hetrombopag demonstrates comparable efficacy and safety to thrombopoietin for platelet engraftment after allogeneic hematopoietic stem cell transplantation, offering a promising alternative in hematologic care.
This trial evaluated low-dose hydrocortisone in cirrhotic patients with septic shock, finding no improvement in 28-day mortality or shock resolution compared to placebo.
Low-dose cadmium exposure during early pregnancy is strongly associated with increased risk of gestational diabetes mellitus, likely via placental metabolic and hormonal alterations.
Low-dose IL-2 immunotherapy demonstrates broad, disease-modifying effects by selectively expanding regulatory T cells (Tregs), offering a promising strategy across diverse diseases including autoimmunity, neurodegeneration, metabolic dysfunction, transplantation, and inflammatory disorders.
High-fiber diets and supplements can aid weight management, improve metabolic health, and reduce obesity-related risks by enhancing digestion, promoting satiety, and regulating blood sugar levels.
A French multicenter study identifies type II cryoglobulinemic vasculitis in primary Sjögren disease as a strong predictor of lymphoma and mortality, necessitating enhanced clinical vigilance.
Waist circumference is a superior predictor of metabolic liver diseases, outperforming BMI and other body metrics in assessing MASLD, MASH, and liver stiffness risks.
The SHIP AHOY Study demonstrates that even modest elevations in blood pressure during adolescence are linked to a greater burden of subclinical target organ injury, underscoring the importance of early detection and intervention.
This article demystifies key clinical trial efficacy endpoints in oncology, including OS, DFS, PFS, ORR, CR, PR, SD, PD, and DCR, providing clinicians with a practical guide to their definitions, roles, and interpretation.
New meta-analysis reveals a strong dose-response relationship between fecal hemoglobin concentration and colorectal neoplasia risk, even among FIT-negative individuals, supporting personalized screening intervals.
PD-1 inhibitor resistance is a major hurdle in cancer immunotherapy. Six leading combination strategies—including chemotherapy, anti-angiogenic agents, radiotherapy, novel checkpoint inhibitors, microbiome modulation, and ADCs—offer new hope for overcoming resistance and improving patient outcomes.
Women with endometriosis exhibit blunted blood pressure responses to physiological stress, challenging prior assumptions about their cardiovascular risk profile. Aspirin, a COX inhibitor, does not modify these attenuated responses.
AI decision support significantly improves primary care clinicians’ accuracy in spirometry diagnosis, especially for COPD, addressing a key gap in respiratory disease management.
Emerging evidence links gut microbiome alterations to hypertension, offering novel therapeutic opportunities. Interventions like dietary fiber, probiotics, and even fecal microbiota transplantation show promise for patients with treatment-resistant hypertension.
Emerging evidence points to a multifactorial etiology of primary hypertension, challenging the traditional kidney-centric perspective and highlighting the need for integrated approaches in prevention and management.
A landmark study quantitatively benchmarks a multi-agent LLM-based AI system against board-certified clinicians in real-world virtual acute care, revealing near-equivalent diagnostic and therapeutic performance with superior documentation safety and consistency.