Specialties – Page 3

Cribriform Morphology’s Impact on Long-term Metastasis Risk in Prostate Cancer: Insights from the PROTECT Trial

By MedXY 10/21/2025

A secondary analysis of the PROTECT trial reveals cribriform-positive prostate cancer significantly elevates 15-year metastasis risk, with radiotherapy plus neoadjuvant ADT reducing this risk more effectively than surgery or active monitoring.

OB/GYN & Women's Health Oncology Radiology Specialties

Personalizing Radiotherapy in Ductal Carcinoma In Situ Using a 12-Gene Expression Assay: Insights from a Prospective Clinical Trial

By MedXY 10/21/2025

This clinical trial prospectively evaluates how a 12-gene expression assay (DCIS score) guides postoperative radiotherapy decisions after breast-conserving surgery in ductal carcinoma in situ, showing tailored radiotherapy use may reduce ipsilateral breast events.

AI Oncology Pathology & Lab Medicine Specialties

Enhancing Melanoma Prognosis: AI-Driven Quantification of Tumor-Infiltrating Lymphocytes Outperforms Traditional Pathology

By MedXY 10/21/2025

This study demonstrates that an AI algorithm provides more reproducible and prognostically relevant assessment of tumor-infiltrating lymphocytes in melanoma compared to traditional pathologist methods, offering a promising tool to improve clinical decision-making.

AI Oncology Pathology & Lab Medicine Specialties

Artificial Intelligence-Detected Tumor-Infiltrating Lymphocytes as a Biomarker in Anti-PD-1-Based Therapy for Advanced Melanoma: Clinical Evidence and Translational Perspectives

By MedXY 10/21/2025

AI-detected tumor-infiltrating lymphocytes on routine histology independently predict response and survival in advanced melanoma treated with anti-PD-1 therapies, outperforming manual scoring and offering an accessible biomarker for immune checkpoint inhibitor outcomes.

AI Oncology Respiratory Specialties

Enhancing Lung Cancer Screening Uptake Through a Direct-to-Patient Digital Health Intervention: Insights from a Randomized Clinical Trial

By MedXY 10/21/2025

A digital health program significantly increased lung cancer screening rates among high-risk individuals, underscoring digital tools' potential to improve preventive care.

患者向けデジタルヘルス介入による肺がんスクリーニング受診率の向上：ランダム化比較試験からの洞察

By MedXY 10/21/2025

デジタルヘルスプログラムは、高リスク個体の肺がんスクリーニング率を大幅に向上させ、予防医療の改善にデジタルツールの潜在力を示しています。

Cardiology news Public Health

Active Monitoring for Atrial Fibrillation (AMALFI): Advancing Long-Term Remote Screening to Reduce Stroke Risk

By MedXY 10/21/2025

The AMALFI trial evaluates remote screening for asymptomatic atrial fibrillation in older adults to improve detection, anticoagulation use, and reduce stroke risk, with findings pending follow-up at 2.5 and 5 years.

Cardiology news Public Health

Remote ECG Patch Screening for Asymptomatic Atrial Fibrillation: Insights from the AMALFI Trial

By MedXY 10/21/2025

The AMALFI trial demonstrates that remote, mail-based 14-day ECG patch screening modestly increases long-term atrial fibrillation detection and anticoagulation use in older adults at stroke risk, with no observed reduction in stroke at 2.5 years.

news Psychiatry

Azetukalner: A Novel KV7 Potassium Channel Opener Shows Promise in Treating Major Depressive Disorder

By MedXY 10/21/2025

Azetukalner, a KV7 potassium channel opener, demonstrated clinically meaningful antidepressant effects and significant improvement in anhedonia in adults with major depressive disorder in a 6-week randomized trial, supporting further development.

Internal Medicine Oncology Specialties

Evaluating Methylphenidate for Fatigue Management in Advanced Cancer: Insights from the MePFAC Randomized Controlled Trial

By MedXY 10/21/2025

The MePFAC trial demonstrates that methylphenidate is safe but does not significantly reduce fatigue compared to placebo in advanced cancer patients receiving palliative care, challenging previous assumptions about its efficacy.

Internal Medicine Psychiatry Specialties

Single-Dose MM120 (Lysergide) Shows Promise in Treating Generalized Anxiety Disorder: Phase 2b RCT Results

By MedXY 10/21/2025

A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.

Cardiology Pediatrics Specialties Transplantation

Everolimus and Low-Dose Tacrolimus Therapy After Pediatric Heart Transplant: Insights from a Multicenter Randomized Clinical Trial

By MedXY 10/21/2025

This randomized trial evaluates the safety and efficacy of everolimus combined with low-dose tacrolimus versus standard immunosuppression in children 6 months post-heart transplant, highlighting comparable rejection rates, improved kidney function, and reduced CMV infection risk.

Neurology Specialties

Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial

By MedXY 10/21/2025

This phase III trial evaluated oral valiltramiprosate in APOEε4/ε4 homozygotes with early Alzheimer's, showing brain atrophy slowing but limited overall clinical benefit, with nominal improvements in mild cognitive impairment subgroups.

Neurology news Pathology & Lab Medicine Psychiatry Specialties

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies

By MedXY 10/21/2025

Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.

Neurology news

Molecular Interplay of TREM2 and ApoE Variants in Alzheimer’s Disease: Structural Insights and Therapeutic Implications

By MedXY 10/21/2025

This article elucidates how TREM2-apoE3 interactions are structurally altered by Alzheimer's-associated TREM2 R47H and apoE4 variants, revealing potential mechanisms that contribute to disease risk and informing therapeutic targeting strategies.

Neurology news Specialties

APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients

By MedXY 10/21/2025

The APOE ε4 allele significantly reduces survival in Parkinson's disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.

Cardiology Neurology news Specialties

Obicetrapib’s Role in Modulating Alzheimer’s Disease Biomarkers in Patients with Cardiovascular Disease: A Landmark Clinical Study

By MedXY 10/21/2025

Obicetrapib, a CETP inhibitor, lowers Alzheimer’s biomarkers like p-tau217 in ASCVD patients, especially ApoE4 carriers, suggesting a potential preventive strategy for high-risk individuals.

Neurology news

Pregnancy Hypertension and Elevated p-tau217: A Midlife Indicator of Alzheimer’s Disease Risk in Women

By MedXY 10/21/2025

Pregnancy hypertension is independently associated with higher serum p-tau217 levels in midlife women, suggesting a link to preclinical Alzheimer’s disease pathology and potential for early screening and intervention.

Neurology Public Health Specialties

Comparative Performance of Dementia Risk Indices in the HUNT Study: Insights into CogDrisk, LIBRA, CAIDE, and More

By MedXY 10/21/2025

This study compares five dementia risk indices using data from the HUNT study, revealing CogDrisk as the most accurate predictor, though none outperformed a demographics-only model including age and education.

Cardiology Family Medicine & Nutrition news Specialties

Dietary Patterns and Intracranial Atherosclerosis Risk in Elderly Patients With Hypertension or Myocardial Infarction: An Evidence-Based Review

By MedXY 10/21/2025

Healthy dietary patterns may reduce intracranial atherosclerosis severity in older adults with hypertension or prior myocardial infarction, suggesting diet's conditional protective role in vascular brain disease.