Colchicine for Long COVID: Randomized Trial Finds No Benefit in Functional Recovery or Inflammatory Resolution
Posted inInfectious Diseases Internal Medicine news

Colchicine for Long COVID: Randomized Trial Finds No Benefit in Functional Recovery or Inflammatory Resolution

A multi-center randomized clinical trial published in JAMA Internal Medicine demonstrates that colchicine, despite its potent anti-inflammatory properties, fails to improve 6-minute walk test distances or inflammatory markers in patients suffering from Long COVID, highlighting the complexity of the condition's pathogenesis.
Selenium Supplementation Fails to Improve Remission or Quality of Life in Graves’ Hyperthyroidism: Findings from the GRASS RCT
Posted inDiabetes & Endocrinology Internal Medicine news

Selenium Supplementation Fails to Improve Remission or Quality of Life in Graves’ Hyperthyroidism: Findings from the GRASS RCT

The GRASS trial, a double-blind multi-centre RCT, found that adding 200 µg of selenium daily to standard antithyroid drug therapy does not increase remission rates or improve quality of life in patients with newly diagnosed Graves' hyperthyroidism, suggesting no clinical benefit for routine supplementation.
Obesity as a Chronic Condition: Weight Regain Following Tirzepatide Withdrawal Reverses Vital Cardiometabolic Gains （SURMOUNT-4 trail）
Posted inCardiology Diabetes & Endocrinology news

Obesity as a Chronic Condition: Weight Regain Following Tirzepatide Withdrawal Reverses Vital Cardiometabolic Gains （SURMOUNT-4 trail）

A post hoc analysis of the SURMOUNT-4 trial reveals that withdrawing tirzepatide leads to significant weight regain and a proportional reversal of improvements in blood pressure, glycemic control, and lipid profiles, reinforcing the necessity for long-term obesity management.
The Limits of Collaborative Care: Why the CLARO Trial Found No Added Benefit for OUD and Comorbid Mental Illness
Posted inInternal Medicine news Psychiatry

The Limits of Collaborative Care: Why the CLARO Trial Found No Added Benefit for OUD and Comorbid Mental Illness

The CLARO randomized clinical trial investigated whether a collaborative care model could improve outcomes for patients with opioid use disorder and co-occurring depression or PTSD. The study found no statistically significant advantages over enhanced usual care, suggesting challenges in implementing these models for complex, low-resource populations.
Superior Durability of Dedicated Balloon-Expandable Bridging Stents in BEVAR: Insights from the BeGraft Peripheral Plus Study
Posted inCardiology General Surgery news

Superior Durability of Dedicated Balloon-Expandable Bridging Stents in BEVAR: Insights from the BeGraft Peripheral Plus Study

A large-scale multicenter study confirms that the BeGraft Peripheral Plus (BGP+) bridging stent graft offers exceptional technical success and high two-year patency rates in branched endovascular aortic repair (BEVAR), establishing it as a reliable dedicated solution for complex aortic aneurysms.
NT-501 Encapsulated Cell Therapy Successfully Slows Photoreceptor Loss in Macular Telangiectasia Type 2: Results from Two Phase 3 Trials
Posted innews Ophthalmology

NT-501 Encapsulated Cell Therapy Successfully Slows Photoreceptor Loss in Macular Telangiectasia Type 2: Results from Two Phase 3 Trials

Two Phase 3 trials show that NT-501 encapsulated cell therapy significantly reduces ellipsoid zone area loss in Macular Telangiectasia Type 2. While functional outcomes were inconsistent, the treatment demonstrated a robust neuroprotective effect against photoreceptor degeneration over 24 months.
Beyond the Golden Years: Young COPD and Early Lung Function Decline as Critical Drivers of Premature Mortality and Cardiovascular Risk
Posted inInternal Medicine news Respiratory

Beyond the Golden Years: Young COPD and Early Lung Function Decline as Critical Drivers of Premature Mortality and Cardiovascular Risk

Recent evidence reveals that COPD in adults under 50 is more prevalent than previously thought, significantly increasing the risk of premature death and heart failure. Furthermore, impaired lung function trajectories starting in childhood predict respiratory symptoms long before a clinical diagnosis of COPD is made.