Specialties – Page 11

Unveiling Distinct Biological Subtypes of Chronic GVHD in Pediatric Hematopoietic Cell Transplantation: Toward Personalized Management

By MedXY 10/14/2025

Recent research identifies three unique biological subtypes of chronic graft-versus-host disease (cGvHD) in children post-hematopoietic cell transplantation, offering potential pathways for tailored treatments and improved outcomes.

Hematology-Oncology news Oncology

Circulating Tumor Cells as Prognostic Biomarkers in Transplant-Eligible Multiple Myeloma Patients Undergoing Frontline Quadruplet Therapy

By MedXY 10/14/2025

Circulating tumor cells (CTCs) serve as an independent prognostic biomarker in transplant-eligible newly diagnosed multiple myeloma patients treated with daratumumab-based quadruplet therapy, predicting progression-free survival and minimal residual disease outcomes.

Hematology-Oncology news Oncology

Busulfan-Melphalan Conditioning Enhances Outcomes in Newly Diagnosed Multiple Myeloma with Reinforced VRD: Insights from the Phase 3 GEM12 Trial

By MedXY 10/14/2025

The phase 3 GEM12 trial compares busulfan-melphalan versus melphalan conditioning in ASCT for newly diagnosed multiple myeloma, showing longer PFS with busulfan-melphalan after intensified VRD induction and consolidation, especially in advanced ISS stages and select genetic subgroups.

Hematology-Oncology news Oncology

Preclinical Progress of Glofitamab Combinations: Pioneering Therapeutics in Non-Hodgkin Lymphoma Management

By MedXY 10/14/2025

Glofitamab, a CD20×CD3 T-cell engager, demonstrates promising synergistic effects in combination with chemotherapy and novel immunotherapies, addressing resistance mechanisms in non-Hodgkin lymphoma preclinical models and supporting future clinical investigation.

Hematology-Oncology news Pediatrics

Molecular Monitoring of MRD in Pediatric AML with KMT2A::MLLT10: Prognostic Insights and Clinical Impact

By MedXY 10/14/2025

MRD monitoring by RT-qPCR in pediatric AML with KMT2A::MLLT10 fusion identifies patients at high risk despite morphologic remission, informing prognosis and guiding therapy.

AI Internal Medicine news

Navigating the AI Revolution in Health Care: Insights from the JAMA Summit

By MedXY 10/14/2025

Artificial intelligence is reshaping health care, offering vast potential benefits alongside significant challenges. The JAMA Summit emphasizes the need for robust evaluation, equitable deployment, and multi-stakeholder collaboration to ensure AI improves outcomes safely and fairly.

Hematology-Oncology Pediatrics Specialties

Personalized Prediction of Platelet Transfusion Outcomes in Preterm Infants with Severe Thrombocytopenia

By MedXY 10/14/2025

A dynamic model predicts individualized risk of major bleeding or death with or without prophylactic platelet transfusion in preterm infants, allowing tailored clinical decisions based on evolving patient status.

Anesthesiology Critical Care General Surgery

Proactive Versus Reactive Intraoperative Blood Pressure Management: Insights from the PRETREAT Randomized Clinical Trial

By MedXY 10/13/2025

The PRETREAT trial found that proactive blood pressure management tailored by risk of intraoperative hypotension does not reduce postoperative functional disability compared to standard care in noncardiac surgery.

Anesthesiology Critical Care news

Individualized Perioperative Blood Pressure Management in Major Abdominal Surgery: Insights from the IMPROVE-multi Trial

By MedXY 10/13/2025

The IMPROVE-multi randomized clinical trial found that tailoring perioperative blood pressure targets to individual preoperative nighttime MAP levels did not reduce postoperative organ injury or mortality compared to routine management in high-risk major abdominal surgery patients.

Internal Medicine Psychiatry

Lithium’s Role in Reducing Suicidal Ideation and Behaviors: An Updated Meta-Analysis of Randomized Controlled Trials

By MedXY 10/12/2025

This systematic review evaluates lithium’s efficacy in reducing suicidal ideation, attempts, and completed suicide, highlighting methodological challenges and the likelihood of benefit despite lack of statistical significance in RCTs.

Diabetes & Endocrinology news Urology

Obesity Interventions and Male Fertility: Unraveling the Effects of Weight Loss on Reproductive Health

By MedXY 10/12/2025

This systematic review and meta-analysis evaluates the effects of obesity interventions—lifestyle modification, pharmacotherapy, and bariatric surgery—on male fertility, highlighting improvements with lifestyle changes and limited benefits from surgical weight loss.

Cardiology Family Medicine & Nutrition news Public Health

Harnessing Flavan-3-ols for Cardiovascular Health: Impacts on Blood Pressure and Endothelial Function

By MedXY 10/12/2025

This systematic review and meta-analysis demonstrates that flavan-3-ol-rich foods significantly lower blood pressure and improve endothelial function, supporting their role in cardiovascular prevention, especially in individuals with elevated or hypertensive baseline blood pressure.

Neurology Psychiatry Specialties

Predicting Seizure Recurrence After a First Unprovoked Seizure: Key Prognostic Factors and Clinical Implications

By MedXY 10/12/2025

This article examines prognostic factors predicting seizure recurrence after a first unprovoked seizure in children and adults, highlighting the roles of EEG abnormalities, brain imaging, nocturnal seizures, and family history, while addressing evidence limitations and future directions.

Gastroenterology General Surgery news

Duct-to-Mucosa versus Other Pancreaticojejunostomy Techniques for Preventing Postoperative Pancreatic Fistula: Updated Evidence and Clinical Insights

By MedXY 10/12/2025

This Cochrane review update evaluates duct-to-mucosa pancreaticojejunostomy compared to other anastomotic techniques following pancreaticoduodenectomy for preventing postoperative pancreatic fistula, finding very low-certainty evidence and no clear superiority of any method.

Neurology news Rehabilitation Medicine

Harnessing Combined Immersive and Nonimmersive Virtual Reality with Mirror Therapy in Stroke Rehabilitation: Evidence from a Systematic Review and Meta-Analysis

By MedXY 10/12/2025

Moderate-quality evidence from 14 RCTs supports combined immersive and nonimmersive VR with mirror therapy to enhance upper extremity function and hand dexterity in stroke survivors, though clinical significance needs cautious interpretation.

news Psychiatry Public Health

Understanding Dropout in Digital Psychosocial Interventions for Adult Illicit Substance Users: Insights from a Systematic Review and Meta-Analysis

By MedXY 10/12/2025

This meta-analysis examines dropout rates in digital psychosocial interventions for adult illicit drug users, identifying key demographic, clinical, and intervention-related factors associated with treatment adherence.

Diabetes & Endocrinology news OB/GYN & Women's Health Specialties

Evaluating Selenium Supplementation in Gestational Diabetes Mellitus: Insights from a Systematic Review and Meta-Analysis

By MedXY 10/12/2025

Selenium supplementation at 200 µg/d may reduce fasting plasma glucose and newborn hyperbilirubinemia risk in gestational diabetes without significantly altering lipid profiles, highlighting potential but limited benefits requiring further research.

Gastroenterology General Surgery news

Da Vinci-Assisted vs Laparoscopic Nissen Fundoplication for GERD: A Critical Systematic Review and Meta-Analysis

By MedXY 10/12/2025

Four RCTs comparing robotic and laparoscopic Nissen fundoplication for GERD show equivalent patient outcomes but longer operative times and higher costs with robotics, questioning its routine use.

news Pediatrics Psychiatry

Decoding the Optimal Aerobic Exercise Dose for Alleviating Depression in Youth: Evidence from a Meta-Analysis

By MedXY 10/12/2025

Aerobic exercise significantly alleviates depressive symptoms in children and adolescents, especially in diagnosed adolescents, with 590 METs-min/week at moderate intensity identified as the optimal dose.

Cardiology news

Long-Term Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement: A Meta-Analysis of Time-to-Event Data

By MedXY 10/12/2025

This meta-analysis evaluates 5-year outcomes comparing TAVI and SAVR across risk profiles, revealing early advantages with TAVI that level off long-term, with no significant difference at 5 years.