OB/GYN & Women’s Health

Scheduled Early-Term Birth: A Proven Strategy to Prevent Pre-eclampsia in High-Risk Pregnancies

By MedXY 01/08/2026

The PREVENT-PE trial demonstrates that risk-stratified scheduled birth at 37–38 weeks reduces pre-eclampsia incidence by 30% without increasing neonatal morbidity or emergency cesarean sections, offering a new standard for late-pregnancy management.

news OB/GYN & Women's Health

Manchester Procedure and Sacrospinous Hysteropexy Yield Equivalent Sexual Function Outcomes in Uterine Prolapse Repair

By MedXY 12/27/2025

This randomized clinical trial analysis confirms that both the Manchester procedure and sacrospinous hysteropexy significantly improve sexual function in women with uterine prolapse, with equivalent outcomes and low rates of de novo dyspareunia at 24 months.

Dermatology news OB/GYN & Women's Health

EMG-Guided Botulinum Toxin Injections Significantly Reduce Pain and Improve Sexual Function in Provoked Vestibulodynia

By MedXY 12/27/2025

A randomized double-blind trial reveals that EMG-guided Onabotulinum toxin A injections effectively alleviate pain and enhance quality of life and sexual satisfaction in women with provoked vestibulodynia, supporting the role of muscular hypertonicity in the condition's pathophysiology.

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Preconception Trace Metal Profiles in Couples: A New Frontier in Optimizing IVF Embryological Outcomes

By MedXY 12/27/2025

A prospective study of 1071 couples identifies that plasma trace metal concentrations in both partners significantly influence IVF success, with elements like iron and molybdenum showing benefits while silver and thallium pose risks to embryo quality.

Diabetes & Endocrinology news OB/GYN & Women's Health

One in Four Premenopausal Women with Type 1 Diabetes Faces Undiagnosed Androgen Excess Disorders

By MedXY 12/27/2025

A cross-sectional study reveals that 26% of women with Type 1 Diabetes suffer from undiagnosed androgen excess, primarily PCOS. The findings emphasize the role of iatrogenic hyperinsulinism and advocate for routine screening, especially for those with premenarcheal diabetes onset.

Clinical Updates news OB/GYN & Women's Health

Emerging Environmental Threats to Ovarian Reserve: The Association Between Novel PFAS Exposure and Premature Ovarian Insufficiency

By MedXY 12/26/2025

This review synthesizes recent clinical evidence identifying novel per- and poly-fluoroalkyl substances (PFAS) as significant risk factors for premature ovarian insufficiency (POI), highlighting their impact on ovarian reserve markers and endocrine health.

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Cumulative Live Birth Rates Plateau at 21–25 Oocytes: New Insights from Follitropin Delta Trials

By MedXY 12/26/2025

A pooled analysis of 1,746 patients demonstrates that while fresh cycle success peaks early, cumulative live birth rates continue to rise with oocyte yield, plateauing at 21–25 oocytes. This benefit is most pronounced in patients aged 38 and older, suggesting age-specific stimulation targets.

news OB/GYN & Women's Health

Does Size Matter? Re-evaluating Endometrial Thickness Thresholds in 30,000 Euploid Embryo Transfers

By MedXY 12/26/2025

An international multicenter study confirms that endometrial thickness below 7 mm reduces live birth rates in most frozen embryo transfer protocols, though the impact is notably absent in natural cycles and overall predictive power remains modest.

news OB/GYN & Women's Health

Challenging the Compaction Paradigm: Why Endometrial Thinning May Not Predict Pregnancy Success in HRT-FET

By MedXY 12/26/2025

A large-scale analysis of over 16,000 cases reveals that endometrial compaction following progesterone administration does not improve pregnancy outcomes in HRT-FET, and may even be associated with lower success rates in blastocyst transfers.

news OB/GYN & Women's Health

Live Birth Rates Independent of Sex-Steroid Levels in Dydrogesterone-Based Programmed-Ovulatory FET: A Shift in Luteal Support Monitoring?

By MedXY 12/26/2025

A multicentric study demonstrates that sex-steroid levels on the day of embryo transfer do not predict live birth rates in a novel programmed-ovulatory FET protocol using dydrogesterone, suggesting that routine hormonal monitoring may be unnecessary when corpus luteum function is preserved.

news OB/GYN & Women's Health Psychiatry

Benzodiazepine Exposure and Adverse Pregnancy Outcomes: New Evidence from a Large-Scale Target Trial Emulation

By MedXY 12/25/2025

A large-scale cohort study emulating randomized trials indicates that benzodiazepine use during pregnancy significantly increases the risk of abortion and preterm birth, even after accounting for competing risks and maternal factors. Risks were most pronounced with second-trimester exposure.

news OB/GYN & Women's Health

ICSI vs. Conventional IVF: New Evidence Suggests No Kinetic Advantage and Lower High-Quality Blastocyst Yield in Non-Male Factor Infertility

By MedXY 12/25/2025

A secondary analysis of the multicentre INVICSI RCT reveals that ICSI results in fewer high-quality Day 5 blastocysts compared to conventional IVF in patients without severe male factor infertility, with no significant differences observed in embryo morphokinetics or cleavage patterns.

news OB/GYN & Women's Health Oncology

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis

By MedXY 12/25/2025

A large-scale multicenter study indicates that cervical stromal invasion is not an independent prognostic factor for survival in early-stage endometrial cancer, challenging traditional staging assumptions when other high-risk features are controlled.

Clinical Updates Diabetes & Endocrinology news OB/GYN & Women's Health

Thyroid Cancer Treatment in Adolescents and Young Adult Women: Impact on Reproductive Outcomes in a Population-Based Cohort

By MedXY 12/25/2025

Thyroid cancer treatments in young women are linked to increased infertility diagnosis and early menopause but show no significant association with premature ovarian insufficiency or reduced childbirth rates.

Cardiology news OB/GYN & Women's Health

Maternal Pre-existing Atherosclerotic Cardiovascular Disease: A Hidden Risk Factor for Neonatal Health and Long-term Neurodevelopment

By MedXY 12/25/2025

A nationwide cohort study demonstrates that maternal pre-existing ASCVD is independently associated with an increased risk of neonatal complications and long-term neurodevelopmental disorders, persisting regardless of adverse pregnancy outcomes.

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Reducing False Positives in Mosaic Embryos Using Parental and Cell-Division Origin Analysis for Preimplantation Genetic Testing

By MedXY 12/24/2025

This study introduces a novel method using parental and cell-division origin analysis to reduce false-positive mosaic embryo diagnoses in preimplantation genetic testing, improving embryo selection and transfer outcomes.

news OB/GYN & Women's Health

Rethinking Mosaicism: Why Reporting Putative Mosaic Embryos Fails to Improve IVF Outcomes

By MedXY 12/24/2025

A large, double-blinded study reveals that reporting embryo mosaicism (ICN) during PGT-A provides no meaningful clinical predictive value for live birth rates, suggesting that current classification systems may unnecessarily limit embryo selection without improving overall success in routine IVF practice.

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Redefining Pelvic Pain: A Validated Diagnostic Threshold for High Tone Pelvic Floor Dysfunction

By MedXY 12/24/2025

A landmark study establishes a data-driven diagnostic threshold for high tone pelvic floor dysfunction (HTPFD), identifying a summative tenderness score of >12/60 as a key clinical marker associated with persistent pain, activity-induced exacerbation, and severe dyspareunia.

General Surgery news OB/GYN & Women's Health

Vaginal Hysterectomy is No Longer the Uncontested Gold Standard: Evidence from a National 10-Year Analysis

By MedXY 12/24/2025

A large-scale analysis of over 83,000 cases reveals that laparoscopic hysterectomy may offer lower complication rates and shorter hospital stays than vaginal hysterectomy, prompting a re-evaluation of current surgical guidelines for benign indications.

news OB/GYN & Women's Health Public Health

Beyond Patient Factors: Modifying Surgical Practice to Mitigate Racial Disparities in Benign Hysterectomy

By MedXY 12/24/2025

This study identifies key modifiable surgical and hospital-level factors—including surgical approach and antibiotic adherence—that contribute to the disproportionately higher rate of postoperative complications experienced by Black patients undergoing benign hysterectomy.