This randomized controlled trial demonstrates that acupuncture improves white matter microstructure on MRI and reduces long-term postconcussion symptoms in mild traumatic brain injury patients, with sustained effects at 6-12 months.
Closed-loop auditory exposure during slow-wave sleep significantly reduces craving and playtime in Internet Gaming Disorder by modulating sleep spindle power, offering a novel, non-invasive therapeutic strategy.
Cognitive behavioural therapy for insomnia enhances self-reported sleep quality and duration, reduces cravings for sweet and savoury foods, and shifts implicit food preferences in adults with overweight or obesity, though dietary intake changes remain uncertain.
The ANGEL-ASPECT trial demonstrates that endovascular therapy (EVT) significantly improves 1-year functional outcomes compared to medical management in patients with large ischemic stroke, confirming durable disability reduction despite similar mortality rates.
This longitudinal study reveals persistent cognitive, physical, and vascular challenges up to 9 years after minor lacunar or cortical ischemic stroke, emphasizing different risks and recovery patterns by stroke subtype.
A 12-week clinical trial reveals that heat-treated green tea extract can significantly improve memory and brain network connectivity in middle-aged adults with subjective memory concerns.
Regular physical activity in early Parkinson disease patients is linked to slower brain atrophy in temporoparietal and limbic regions, mediating better preservation of memory and attention over four years.
A tailored, app-supported exercise program delivered via mobile health significantly improves core ADHD symptoms and executive functions in children, demonstrating comparable effectiveness to traditional face-to-face exercise guidance.
A decade of research highlights cinnamon's benefits in glycemic control, lipid modulation, anti-inflammatory effects, cognitive enhancement, and antimicrobial activity, supporting its adjunctive clinical use and revealing promising therapeutic directions.
This review synthesizes 10 years of sulforaphane (SFN) research, highlighting its pharmacology, clinical trial outcomes, and emerging therapeutic prospects across cancer, metabolic, renal, neurodevelopmental, and cardiovascular disorders.
Stroke, a sudden interruption of brain blood flow, can lead to severe disability or death but is largely preventable. Early recognition and timely intervention can save lives and reduce complications.
The SAPPHIRE phase 3 trial found that adding apitegromab to nusinersen or risdiplam produced a small but statistically significant improvement in motor function in children aged 2–12, with a safety profile similar to placebo.
Nearly 60% of dementia cases in Brazil could be prevented by addressing 14 modifiable risk factors, highlighting a crucial public health opportunity in a middle-income country setting.
This study presents compelling evidence that pre-clinical Alzheimer’s disease increases systolic blood pressure, using innovative Mendelian randomisation and parental dementia instruments in UK Biobank data. These findings highlight complex vascular interactions preceding clinical dementia.
Exosomes, nanoscale vesicles capable of crossing the blood–brain barrier, hold significant potential as targeted therapeutic agents and diagnostic markers in neurodegenerative diseases. Advances in genetic, chemical, and nanomaterial modifications enhance their targeting, representing a promising frontier for treatment.
The FDA has approved Tonmya (sublingual cyclobenzaprine) as the first new fibromyalgia therapy in 15 years, targeting nonrestorative sleep to alleviate pain, fatigue, and cognitive symptoms in adults.
A meta-analysis of over 2000 stroke patients found that intravenous thrombolysis (IVT) before endovascular treatment (EVT) modestly increases intracranial hemorrhage (ICH) risk, especially in patients with elevated glucose and blood pressure, though functional benefits may still outweigh risks.
Elevated prenatal chlorpyrifos exposure is linked to widespread brain structural abnormalities, reduced neuronal density, and impaired motor functions in children, underscoring the need for exposure minimization during pregnancy.