Neurology – Medxy AI

ESCAPE-NEXT Trial: Nerinetide Fails to Improve Functional Outcomes in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy Without Prior Thrombolysis

By MedXY 10/22/2025

The ESCAPE-NEXT trial evaluated nerinetide for acute ischaemic stroke patients undergoing thrombectomy without prior thrombolysis. Nerinetide showed no significant improvement in functional outcomes or safety concerns, highlighting the need for further research into optimal patient selection and treatment timing.

Cardiology Neurology Specialties

Long-Term Stroke Risk in Healthy Women: The Predictive Role of hsCRP, LDL Cholesterol, and Lipoprotein(a)

By MedXY 10/22/2025

A 30-year prospective study reveals that elevated hsCRP, LDL cholesterol, and lipoprotein(a) levels independently and collectively increase the risk of ischaemic stroke in healthy women, advocating for early biomarker screening in stroke prevention.

Infectious Diseases Neurology Otorhinolaryngology Specialties

Persistent Olfactory Dysfunction Following SARS-CoV-2 Infection: Insights from the RECOVER Adult Cohort

By MedXY 10/22/2025

A large prospective study demonstrates that olfactory dysfunction is prevalent and often clinically unrecognized long after SARS-CoV-2 infection, highlighting the value of formal smell testing in patient care and cognitive risk assessment.

Neurology news

Severe Symptomatic Arterial Vasospasm Following Pituitary Surgery: A Rare Case and Systematic Review of the Literature

By MedXY 10/22/2025

We report a rare case of severe symptomatic arterial vasospasm after pituitary surgery, accompanied by a systematic review highlighting risk factors, clinical presentation, treatment strategies, and outcomes for this life-threatening complication.

Emergency Medicine Neurology Rehabilitation Medicine Specialties

Evaluating Telestroke’s Impact on Acute Ischemic Stroke Treatment Timeliness and Outcomes

By MedXY 10/22/2025

Telestroke evaluation increases thrombolysis rates but is associated with longer treatment times and delays in patient transfers in acute ischemic stroke, highlighting the need to address modifiable treatment delays.

Neurology Specialties

Early Intravenous Immunoglobulin Therapy Improves Long-Term Outcomes in Anti-IgLON5 Disease

By MedXY 10/22/2025

This retrospective multicenter study found that early intravenous immunoglobulin treatment in anti-IgLON5 disease is linked to reduced disability and mortality, highlighting a promising immunotherapeutic strategy for this rare autoimmune encephalopathy.

General Surgery Neurology Rehabilitation Medicine Specialties

Impact of Early Extracranial Surgery on One-Year Outcomes After Traumatic Brain Injury: Insights from the TRACK-TBI Study

By MedXY 10/21/2025

Early extracranial surgery following moderate-severe traumatic brain injury or positive CT findings is linked to worse cognitive, functional, and quality of life outcomes at one year, highlighting the need to refine surgical timing and post-injury interventions.

Neurology news Rehabilitation Medicine Specialties

Evaluating Electromagnetic Network-Targeted Field Therapy for Post-Ischemic Stroke Disability: Insights from the EMAGINE Trial

By MedXY 10/21/2025

The EMAGINE randomized clinical trial assessed low-intensity electromagnetic stimulation combined with rehabilitation in moderate to severe ischemic stroke patients. While safe, it did not yield statistically significant functional improvement, warranting further investigation.

Clinical Updates Neurology Specialties

Transcutaneous Peripheral Nerve Stimulation for Essential Tremor: Advancements from a 2024 Randomized Clinical Trial and Evolving Evidence

By MedXY 10/21/2025

AI-driven transcutaneous peripheral nerve stimulation (TPNS) shows significant improvements in upper limb function for essential tremor (ET), supporting a promising noninvasive treatment approach with manageable safety profile over 90 days.

Neurology Specialties

Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial

By MedXY 10/21/2025

This phase III trial evaluated oral valiltramiprosate in APOEε4/ε4 homozygotes with early Alzheimer's, showing brain atrophy slowing but limited overall clinical benefit, with nominal improvements in mild cognitive impairment subgroups.

Neurology news Pathology & Lab Medicine Psychiatry Specialties

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies

By MedXY 10/21/2025

Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.

Neurology news

Molecular Interplay of TREM2 and ApoE Variants in Alzheimer’s Disease: Structural Insights and Therapeutic Implications

By MedXY 10/21/2025

This article elucidates how TREM2-apoE3 interactions are structurally altered by Alzheimer's-associated TREM2 R47H and apoE4 variants, revealing potential mechanisms that contribute to disease risk and informing therapeutic targeting strategies.

Neurology news Specialties

APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients

By MedXY 10/21/2025

The APOE ε4 allele significantly reduces survival in Parkinson's disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.

Cardiology Neurology news Specialties

Obicetrapib’s Role in Modulating Alzheimer’s Disease Biomarkers in Patients with Cardiovascular Disease: A Landmark Clinical Study

By MedXY 10/21/2025

Obicetrapib, a CETP inhibitor, lowers Alzheimer’s biomarkers like p-tau217 in ASCVD patients, especially ApoE4 carriers, suggesting a potential preventive strategy for high-risk individuals.

Neurology news

Pregnancy Hypertension and Elevated p-tau217: A Midlife Indicator of Alzheimer’s Disease Risk in Women

By MedXY 10/21/2025

Pregnancy hypertension is independently associated with higher serum p-tau217 levels in midlife women, suggesting a link to preclinical Alzheimer’s disease pathology and potential for early screening and intervention.

Neurology Public Health Specialties

Comparative Performance of Dementia Risk Indices in the HUNT Study: Insights into CogDrisk, LIBRA, CAIDE, and More

By MedXY 10/21/2025

This study compares five dementia risk indices using data from the HUNT study, revealing CogDrisk as the most accurate predictor, though none outperformed a demographics-only model including age and education.

Neurology news Specialties

Rapamycin for Alzheimer’s Prevention in APOE4 Carriers: Restoring Brain Metabolism and Vascular Health

By MedXY 10/21/2025

Rapamycin shows promise in preventing Alzheimer's disease in APOE4 carriers by improving brain mitochondrial function, synaptic activity, and vascular health, highlighting a potential genotype-targeted early intervention for this high-risk population.

Neurology Pathology & Lab Medicine Specialties

APOE4 Amplifies Blood Biomarkers’ Association with Cognitive Decline in Aging Adults: Insights from a Biracial 20-Year Cohort Study

By MedXY 10/21/2025

This study reveals that APOE4 carriers with elevated blood neurodegenerative biomarkers experience accelerated cognitive decline, highlighting the gene's role in exacerbating neurodegeneration among community-dwelling older adults without dementia.

Family Medicine & Nutrition Neurology news Specialties

APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo

By MedXY 10/21/2025

This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African populations.

Family Medicine & Nutrition Neurology news Specialties

Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort

By MedXY 10/20/2025

A 4-year longitudinal study reveals that long-duration, high-intensity lifetime walking is associated with reduced amyloid-β accumulation in older adults, suggesting a neuroprotective effect when initiated early in life.