Metformin and ‘Anti‑Aging’: Promising Mechanisms but Mixed Clinical Evidence — What Recent Trials Tell Us
Posted inClinical Updates Family Medicine & Nutrition Internal Medicine news Specialties

Metformin and ‘Anti‑Aging’: Promising Mechanisms but Mixed Clinical Evidence — What Recent Trials Tell Us

Recent randomized and mechanistic studies provide a nuanced view: metformin shows plausible anti‑aging mechanisms and microbiome‑linked cognitive associations, but randomized trials report no clear anti‑cancer or anti‑senescence effects in humans to date.
Urolithin A for Muscle Health: A 4‑Month Randomized Trial Shows Improved Lower‑Limb Strength, Endurance Signals, and Mitochondrial Biomarkers
Posted inClinical Updates Family Medicine & Nutrition Internal Medicine news Specialties

Urolithin A for Muscle Health: A 4‑Month Randomized Trial Shows Improved Lower‑Limb Strength, Endurance Signals, and Mitochondrial Biomarkers

In a randomized, double‑blind 4‑month trial of middle‑aged overweight adults, oral urolithin A improved hamstring strength (~10–12%), increased peak VO2 and 6‑minute walk distance (clinically meaningful at 33 m for 1,000 mg), altered mitochondrial proteomic signatures, and reduced inflammation without major safety signals.
Dissecting Depression in Diabetes: Distinct Links of Somatic and Cognitive Symptoms with Inflammation and Insulin Resistance
Posted inClinical Updates Diabetes & Endocrinology Internal Medicine news Psychiatry Specialties

Dissecting Depression in Diabetes: Distinct Links of Somatic and Cognitive Symptoms with Inflammation and Insulin Resistance

New GRADE sub-study reveals that somatic symptoms of depression, not cognitive-affective symptoms, are chiefly associated with inflammation and insulin resistance in type 2 diabetes, highlighting a pathophysiological bridge for targeted interventions.