Medxy AI – Page 182

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

By MedXY 07/31/2025

The ANGEL-TNK trial found that intra-arterial tenecteplase after successful endovascular thrombectomy improved excellent neurological outcomes at 90 days without increasing bleeding or mortality, but secondary outcomes showed no significant benefit.

Clinical Updates news

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

By MedXY 07/31/2025

Clinical Updates Dermatology Infectious Diseases news Specialties

Dual IL-17A/F Blockade and Increased Candidiasis Risk

By MedXY 07/31/2025

Blocking both IL-17A and IL-17F impairs neutrophil migration, reducing antifungal defense and raising candidiasis risk in patients on bimekizumab, according to in vitro evidence.

Clinical Updates news Oncology Orthopedics Specialties

Inconsistent Bone Health Management in Older Women With Breast Cancer: Insights From the Age Gap Study

By MedXY 07/31/2025

Significant variation exists in bone health management for older women receiving endocrine therapy for breast cancer, highlighting the need for standardized care.

Clinical Updates

多発性筋痛症が死亡リスクの増加と関連しないこと：38年間のノルウェー集団研究からの洞察

By MedXY 07/31/2025

ノルウェー南部での38年間の前向き研究は、単独の多発性筋痛症（PMR）が対照群と比較して全原因による死亡リスクを増加させないことを示しています。男性ではさらに低い死亡リスクが見られました。

Clinical Updates news Rheumatology Specialties

Polymyalgia Rheumatica Not Associated with Increased Mortality: Insights from a 38-Year Norwegian Cohort Study

By MedXY 07/31/2025

A 38-year prospective study in Southern Norway demonstrates that isolated polymyalgia rheumatica (PMR) does not increase all-cause mortality compared to matched population controls, with men showing even lower mortality risk.

Clinical Updates news Oncology Specialties

ED Intubation in Active Hemorrhage Linked to Increased Mortality: Insights from a Nationwide Cohort Study

By MedXY 07/31/2025

Intubation in the emergency department for trauma patients with active hemorrhage is associated with higher mortality, more ICU admissions, and greater transfusion needs compared to intubation in the operating room.

Clinical Updates Diabetes & Endocrinology news Ophthalmology Specialties

Veligrotug Emerges as a Promising Therapy for Thyroid Eye Disease: Insights from the THRIVE and THRIVE-2 Trials

By MedXY 07/31/2025

Veligrotug demonstrates robust efficacy and manageable safety in both active and chronic thyroid eye disease, positioning itself as a potential alternative to teprotumumab based on phase 3 THRIVE trial data.

Gastroenterology Medical News news Specialties

Sharp Rise in Advanced Alcohol-Related Liver Disease Despite Stable Drinking Rates: Changing Population Risks Highlighted by US Data

By MedXY 07/31/2025

A twofold rise in advanced liver fibrosis among US heavy drinkers over two decades is linked to increased metabolic syndrome, age, and socioeconomic risk, not higher alcohol intake.

Anesthesiology Clinical Updates Critical Care news Pediatrics Specialties

Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation

By MedXY 07/31/2025

A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.

Family Medicine & Nutrition news Pediatrics Public Health Specialties

Sweetener Consumption and Genetic Predisposition: New Insights into Early Puberty Risk in Children

By Dr.Paul 07/31/2025

Sweetener intake, especially aspartame and sucralose, is linked to increased risk of early puberty in genetically predisposed children, with notable sex-specific differences

Medical News news

Benzene in Acne Products: Clinical Implications, Risks, and Regulatory Response

By MedXY 07/31/2025

Recent findings of benzene in benzoyl peroxide acne products have sparked debate, recalls, and regulatory scrutiny, prompting calls for improved safety measures despite the continued clinical utility of these therapies.

Clinical Updates news Oncology Specialties

Ovarian Cancer Risk Peaks Shortly After New IBS Diagnosis: Clinical Implications and Evidence Review

By MedXY 07/31/2025

A new IBS diagnosis is associated with a transiently increased risk of ovarian cancer, especially within the first 6 months, emphasizing the need for heightened clinical vigilance.

Clinical Updates Dermatology news Specialties

Rapid Initial Benefits of Secukinumab in Early Psoriatic Arthritis: Insights from a Treat-to-Target Randomized Trial

By MedXY 07/31/2025

Early secukinumab use in newly diagnosed psoriatic arthritis delivers faster clinical improvement at 3 months compared to standard care, but this advantage diminishes by 6 months and beyond.

Clinical Updates Medical News Pediatrics Public Health Specialties

Aluminum-Adjuvanted Vaccines in Early Childhood and Risk of Chronic Autoimmune, Allergic, and Neurodevelopmental Disorders: Insights from a Danish Nationwide Cohort Study

By MedXY 07/31/2025

A comprehensive Danish cohort study finds no evidence linking early childhood aluminum-adsorbed vaccines to increased risks of autoimmune, allergic, or neurodevelopmental disorders, supporting vaccine safety.

Clinical Updates Diabetes & Endocrinology Gastroenterology news Specialties

GLP-1 Receptor Agonists and Risk of GERD in Type 2 Diabetes: Clinical Implications from a Large Population-Based Cohort Study

By MedXY 07/31/2025

GLP-1 receptor agonists modestly increase the risk of GERD and its complications compared to SGLT-2 inhibitors in type 2 diabetes patients, highlighting the need for vigilant symptom monitoring.

Clinical Updates Diabetes & Endocrinology news Specialties

Weekend Warrior Exercise Patterns: Comparable Cardiometabolic Protection to Regular Activity in Diabetes and MASLD

By MedXY 07/31/2025

Accumulating 150 minutes of moderate-to-vigorous physical activity weekly, either as a 'weekend warrior' or in regular sessions, significantly reduces mortality and cardiometabolic risk in adults with diabetes and MASLD.

Clinical Updates Diabetes & Endocrinology news Specialties

GLP-1 Receptor Agonists and Dementia Risk in Older Adults With Type 2 Diabetes: Insights From a Target Trial Emulation

By MedXY 07/31/2025

A large-scale emulated trial found no clear overall reduction in dementia risk with GLP-1 receptor agonists versus DPP-4 inhibitors in older adults with type 2 diabetes, though age-specific effects warrant further investigation.

Clinical Updates Medical News Orthopedics Specialties

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis: Evidence from a Randomized Controlled Trial

By MedXY 07/31/2025

A randomized trial demonstrates that medial opening wedge high tibial osteotomy (HTO) slows cartilage loss and improves symptoms in patients with medial compartment knee osteoarthritis and varus alignment, supporting its role as a joint-preserving intervention.

Clinical Updates news Rheumatology Specialties

Rituximab Shows No Superiority Over Conventional Therapy for EGPA Remission Induction

By MedXY 07/31/2025

A phase 3 randomized trial found rituximab no more effective than standard glucocorticoid-based therapy in inducing remission in eosinophilic granulomatosis with polyangiitis (EGPA), with comparable safety and relapse profiles.

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

Dual IL-17A/F Blockade and Increased Candidiasis Risk

Inconsistent Bone Health Management in Older Women With Breast Cancer: Insights From the Age Gap Study

多発性筋痛症が死亡リスクの増加と関連しないこと：38年間のノルウェー集団研究からの洞察

Polymyalgia Rheumatica Not Associated with Increased Mortality: Insights from a 38-Year Norwegian Cohort Study

ED Intubation in Active Hemorrhage Linked to Increased Mortality: Insights from a Nationwide Cohort Study

Veligrotug Emerges as a Promising Therapy for Thyroid Eye Disease: Insights from the THRIVE and THRIVE-2 Trials

Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation

Sweetener Consumption and Genetic Predisposition: New Insights into Early Puberty Risk in Children

Benzene in Acne Products: Clinical Implications, Risks, and Regulatory Response

Ovarian Cancer Risk Peaks Shortly After New IBS Diagnosis: Clinical Implications and Evidence Review

Rapid Initial Benefits of Secukinumab in Early Psoriatic Arthritis: Insights from a Treat-to-Target Randomized Trial

Aluminum-Adjuvanted Vaccines in Early Childhood and Risk of Chronic Autoimmune, Allergic, and Neurodevelopmental Disorders: Insights from a Danish Nationwide Cohort Study

GLP-1 Receptor Agonists and Risk of GERD in Type 2 Diabetes: Clinical Implications from a Large Population-Based Cohort Study

Weekend Warrior Exercise Patterns: Comparable Cardiometabolic Protection to Regular Activity in Diabetes and MASLD

GLP-1 Receptor Agonists and Dementia Risk in Older Adults With Type 2 Diabetes: Insights From a Target Trial Emulation

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis: Evidence from a Randomized Controlled Trial

Rituximab Shows No Superiority Over Conventional Therapy for EGPA Remission Induction

Beyond Glycemic Control: Empagliflozin/Linagliptin Combination Restores Urinary Microbiota Homeostasis in Type 2 Diabetes

Bridging the Gap: Understanding In-Procedure Variability and Quality Control in the FAVOR III Europe QFR Analysis

Diminished Circadian Heart Rate Fluctuations: A Potent Predictor of 21-Year Mortality in Patients with Diabetes

Haptoglobin 1-1 and Low Protein Levels: Identifying the Lowest Cardiovascular Risk in Type 2 Diabetes