Subclinical elevations of high-sensitivity cardiac troponin I (hs-cTnI), even below the 99th percentile for myocardial injury, predict increased risk of late-life dementia (LLD) in older women.
In a 14.5-year longitudinal cohort study, higher quartiles of hs-cTnI correlated with higher incidence of LLD events, hospitalisations, and dementia-related deaths, independent of APOE genotype and established risk factors.
Hs-cTnI may serve as a valuable biomarker integrating cardiovascular and neurodegenerative disease risk, supporting the interconnected pathophysiology between cardiac and brain health vulnerabilities in ageing.
