Nitrous Oxide as an Effective Analgesic in Office Operative Hysteroscopy: Insights from a Randomized Controlled Trial

Highlight

Inhaled nitrous oxide (N2O) significantly reduced intraprocedural pain during office operative hysteroscopy compared to placebo (ambient air). The analgesic effect was notably stronger in postmenopausal women. Use of N2O improved procedure completion rates and patient satisfaction with a low rate of adverse events.

Study Background and Clinical Context