Highlights
In this large population-based Norwegian cohort, greater midlife central adiposity, assessed by waist-to-height ratio, was associated with higher late-life plasma p-tau217 and higher risk of biomarker-verified Alzheimer disease dementia.
The signal was not limited to central adiposity. Body mass index showed a similar life-course pattern, with midlife obesity linked to higher late-life Alzheimer biomarker burden.
