Background
Optimal nutritional support for critically ill patients remains a contentious topic in intensive care medicine. While malnutrition is associated with poor outcomes, the risks of overfeeding—particularly in patients with shock—are increasingly recognized. The NUTRIREA-3 trial originally compared low versus standard calorie and protein intake in mechanically ventilated adults with shock. This post hoc analysis specifically examines the impact of these nutritional strategies on renal function, a critical consideration given the high prevalence of acute kidney injury (AKI) in this population.
