In Transition-Age Childhood-Onset GH Deficiency, Glucagon Test Results Reflect Pituitary Damage More Than Body Mass Index

Highlights

The glucagon stimulation test (GST) in transition-age patients with childhood-onset growth hormone deficiency (CO-GHD) appears to track the severity of hypothalamic-pituitary damage more closely than adiposity.

Although peak GH after glucagon was inversely correlated with BMI standard deviation score, this association weakened substantially after adjustment for disease category, suggesting confounding by etiology.

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